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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
8
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pubmed:dateCreated |
1974-12-16
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pubmed:abstractText |
The translations of native messenger RNA for rabbit globin and that of poly(A)-free globin messenger RNA have been compared after injection into Xenopus oocytes. The initial rate of translation of poly(A)-free mRNA is close to that found with intact mRNA. However, at longer incubation periods, the rate of globin synthesis with poly(A)-free mRNA is considerably lower than with native mRNA. Similar differences in the template activity of the two mRNA preparations were found with a cell-free extract of Krebs II ascites tumor. It is concluded that the presence of the 3' poly(A)-rich sequence in mRNA is required to ensure high functional stability.
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/4528715-4129862,
http://linkedlifedata.com/resource/pubmed/commentcorrection/4528715-4352974,
http://linkedlifedata.com/resource/pubmed/commentcorrection/4528715-4504350,
http://linkedlifedata.com/resource/pubmed/commentcorrection/4528715-4511912,
http://linkedlifedata.com/resource/pubmed/commentcorrection/4528715-4536742,
http://linkedlifedata.com/resource/pubmed/commentcorrection/4528715-4539023,
http://linkedlifedata.com/resource/pubmed/commentcorrection/4528715-4542191,
http://linkedlifedata.com/resource/pubmed/commentcorrection/4528715-4796973,
http://linkedlifedata.com/resource/pubmed/commentcorrection/4528715-4939175,
http://linkedlifedata.com/resource/pubmed/commentcorrection/4528715-4965168,
http://linkedlifedata.com/resource/pubmed/commentcorrection/4528715-5169491,
http://linkedlifedata.com/resource/pubmed/commentcorrection/4528715-5472357,
http://linkedlifedata.com/resource/pubmed/commentcorrection/4528715-5500401
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Aug
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pubmed:issn |
0027-8424
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
71
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
3143-6
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pubmed:dateRevised |
2009-11-18
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pubmed:meshHeading |
pubmed-meshheading:4528715-Adenine Nucleotides,
pubmed-meshheading:4528715-Animals,
pubmed-meshheading:4528715-Anura,
pubmed-meshheading:4528715-Carcinoma, Krebs 2,
pubmed-meshheading:4528715-Cell-Free System,
pubmed-meshheading:4528715-Chromatography, Gel,
pubmed-meshheading:4528715-Female,
pubmed-meshheading:4528715-Globins,
pubmed-meshheading:4528715-Half-Life,
pubmed-meshheading:4528715-Hemoglobins,
pubmed-meshheading:4528715-Histidine,
pubmed-meshheading:4528715-Ovum,
pubmed-meshheading:4528715-Polynucleotides,
pubmed-meshheading:4528715-Protein Biosynthesis,
pubmed-meshheading:4528715-RNA, Messenger,
pubmed-meshheading:4528715-RNA, Neoplasm,
pubmed-meshheading:4528715-Rabbits,
pubmed-meshheading:4528715-Templates, Genetic,
pubmed-meshheading:4528715-Time Factors,
pubmed-meshheading:4528715-Tritium,
pubmed-meshheading:4528715-Xenopus
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pubmed:year |
1974
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pubmed:articleTitle |
Role of the polyadenylate segment in the translation of globin messenger RNA in Xenopus oocytes.
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pubmed:publicationType |
Journal Article
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