| pubmed-article:4527189 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:4527189 | lifeskim:mentions | umls-concept:C0030705 | lld:lifeskim |
| pubmed-article:4527189 | lifeskim:mentions | umls-concept:C0013216 | lld:lifeskim |
| pubmed-article:4527189 | lifeskim:mentions | umls-concept:C0085669 | lld:lifeskim |
| pubmed-article:4527189 | lifeskim:mentions | umls-concept:C0020987 | lld:lifeskim |
| pubmed-article:4527189 | lifeskim:mentions | umls-concept:C0031082 | lld:lifeskim |
| pubmed-article:4527189 | lifeskim:mentions | umls-concept:C2603343 | lld:lifeskim |
| pubmed-article:4527189 | pubmed:issue | 2 | lld:pubmed |
| pubmed-article:4527189 | pubmed:dateCreated | 1974-10-4 | lld:pubmed |
| pubmed-article:4527189 | pubmed:abstractText | Immunocompetence was followed serially for 1 yr from the onset of treatment in 55 adult patients with acute leukemia. The tests used were delayed hypersensitivity responses to a battery of five recall antigens (dermatophytin, dermatophytin 0, candida, streptokinase-streptodornase, and mumps) and in vitro lymphocyte blastogenic responses to phytohemagglutinin and streptolysin 0. There was a strong correlation between immunocompetence at the start of treatment and a good prognosis; 32/39 patients who subsequently entered remission were initially immunocompetent compared to 4/15 who failed to enter remission. In the complete remission group there was a decline in competence starting from 2 to 5 mo after the onset of treatment. In those who remained in remission for 1 yr, competence recovered at 6 mo and remained vigorous thereafter. In those who relapsed before 1 yr, the decline in competence occurred 1 mo before relapse and competence continued to decline progressively during the 1 yr follow-up period. These studies suggest that therapeutic approaches which restore immunocompetence or prevent its decline will improve both the remission rate and the remission duration of patients with acute leukemia. | lld:pubmed |
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| pubmed-article:4527189 | pubmed:language | eng | lld:pubmed |
| pubmed-article:4527189 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:4527189 | pubmed:citationSubset | AIM | lld:pubmed |
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| pubmed-article:4527189 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:4527189 | pubmed:month | Aug | lld:pubmed |
| pubmed-article:4527189 | pubmed:issn | 0021-9738 | lld:pubmed |
| pubmed-article:4527189 | pubmed:author | pubmed-author:McCredieK BKB | lld:pubmed |
| pubmed-article:4527189 | pubmed:author | pubmed-author:HershE MEM | lld:pubmed |
| pubmed-article:4527189 | pubmed:author | pubmed-author:FreireichE... | lld:pubmed |
| pubmed-article:4527189 | pubmed:author | pubmed-author:BurgessM AMA | lld:pubmed |
| pubmed-article:4527189 | pubmed:author | pubmed-author:GuttermanJ... | lld:pubmed |
| pubmed-article:4527189 | pubmed:author | pubmed-author:MatthewsAA | lld:pubmed |
| pubmed-article:4527189 | pubmed:author | pubmed-author:MavligitG MGM | lld:pubmed |
| pubmed-article:4527189 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:4527189 | pubmed:volume | 54 | lld:pubmed |
| pubmed-article:4527189 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:4527189 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:4527189 | pubmed:pagination | 401-8 | lld:pubmed |
| pubmed-article:4527189 | pubmed:dateRevised | 2009-11-18 | lld:pubmed |
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| pubmed-article:4527189 | pubmed:year | 1974 | lld:pubmed |
| pubmed-article:4527189 | pubmed:articleTitle | Serial studies of immunocompetence of patients undergoing chemotherapy for acute leukemia. | lld:pubmed |
| pubmed-article:4527189 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:4527189 | pubmed:publicationType | In Vitro | lld:pubmed |
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