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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
2
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pubmed:dateCreated |
1974-10-4
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pubmed:abstractText |
Immunocompetence was followed serially for 1 yr from the onset of treatment in 55 adult patients with acute leukemia. The tests used were delayed hypersensitivity responses to a battery of five recall antigens (dermatophytin, dermatophytin 0, candida, streptokinase-streptodornase, and mumps) and in vitro lymphocyte blastogenic responses to phytohemagglutinin and streptolysin 0. There was a strong correlation between immunocompetence at the start of treatment and a good prognosis; 32/39 patients who subsequently entered remission were initially immunocompetent compared to 4/15 who failed to enter remission. In the complete remission group there was a decline in competence starting from 2 to 5 mo after the onset of treatment. In those who remained in remission for 1 yr, competence recovered at 6 mo and remained vigorous thereafter. In those who relapsed before 1 yr, the decline in competence occurred 1 mo before relapse and competence continued to decline progressively during the 1 yr follow-up period. These studies suggest that therapeutic approaches which restore immunocompetence or prevent its decline will improve both the remission rate and the remission duration of patients with acute leukemia.
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/4527189-14332475,
http://linkedlifedata.com/resource/pubmed/commentcorrection/4527189-4116319,
http://linkedlifedata.com/resource/pubmed/commentcorrection/4527189-4182654,
http://linkedlifedata.com/resource/pubmed/commentcorrection/4527189-4354467,
http://linkedlifedata.com/resource/pubmed/commentcorrection/4527189-4513355,
http://linkedlifedata.com/resource/pubmed/commentcorrection/4527189-4565852,
http://linkedlifedata.com/resource/pubmed/commentcorrection/4527189-4582620,
http://linkedlifedata.com/resource/pubmed/commentcorrection/4527189-4708150,
http://linkedlifedata.com/resource/pubmed/commentcorrection/4527189-4708575,
http://linkedlifedata.com/resource/pubmed/commentcorrection/4527189-4921480,
http://linkedlifedata.com/resource/pubmed/commentcorrection/4527189-5286447,
http://linkedlifedata.com/resource/pubmed/commentcorrection/4527189-5286519,
http://linkedlifedata.com/resource/pubmed/commentcorrection/4527189-5413507,
http://linkedlifedata.com/resource/pubmed/commentcorrection/4527189-5447018,
http://linkedlifedata.com/resource/pubmed/commentcorrection/4527189-5790283,
http://linkedlifedata.com/resource/pubmed/commentcorrection/4527189-5844228
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
AIM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Aug
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pubmed:issn |
0021-9738
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
54
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
401-8
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pubmed:dateRevised |
2009-11-18
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pubmed:meshHeading |
pubmed-meshheading:4527189-Adolescent,
pubmed-meshheading:4527189-Adult,
pubmed-meshheading:4527189-Aged,
pubmed-meshheading:4527189-Antibody Formation,
pubmed-meshheading:4527189-Antineoplastic Agents,
pubmed-meshheading:4527189-Cyclophosphamide,
pubmed-meshheading:4527189-Cytarabine,
pubmed-meshheading:4527189-Drug Therapy, Combination,
pubmed-meshheading:4527189-Follow-Up Studies,
pubmed-meshheading:4527189-Humans,
pubmed-meshheading:4527189-Hypersensitivity, Delayed,
pubmed-meshheading:4527189-Immunotherapy,
pubmed-meshheading:4527189-Lectins,
pubmed-meshheading:4527189-Leukemia,
pubmed-meshheading:4527189-Leukemia, Lymphoid,
pubmed-meshheading:4527189-Leukemia, Myeloid, Acute,
pubmed-meshheading:4527189-Lymphocyte Activation,
pubmed-meshheading:4527189-Lymphocytes,
pubmed-meshheading:4527189-Middle Aged,
pubmed-meshheading:4527189-Prednisone,
pubmed-meshheading:4527189-Prognosis,
pubmed-meshheading:4527189-Remission, Spontaneous,
pubmed-meshheading:4527189-Skin Tests,
pubmed-meshheading:4527189-Streptolysins,
pubmed-meshheading:4527189-Vincristine
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pubmed:year |
1974
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pubmed:articleTitle |
Serial studies of immunocompetence of patients undergoing chemotherapy for acute leukemia.
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pubmed:publicationType |
Journal Article,
In Vitro
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