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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
2
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pubmed:dateCreated |
1973-9-26
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pubmed:abstractText |
After one passage of influenza A2/Singapore/1/57 virus in mice treated with 150 mg./kg./day of aminoadamantane, a partially drug-resistant strain of virus was detected in 1 of 12 mice. The isolation rate of aminoadamantane-resistant viruses increased to 8 after three passages in drug-treated mice. Some virus strains showed a 500-fold increase in resistance to aminoadamantane and to the structurally related compounds alpha-methyl-1-adamantane methylamine and 2-adamantanamine sulphate. No aminoadamantane-resistant viruses were detected after passage of influenza four times in mice treated with lower (15 or 1.5 mg./kg./day) concentrations of aminoadamantane. Aminoadamantane had no detectable effect on the development of lung lesions in mice infected with the drug-resistant influenza strain, whereas lung lesions were reduced in aminoadamantane treated mice infected with a control strain of influenza A2/Singapore virus. No differences were detected in the buoyant density in caesium chloride, morphology or serology between control and aminoadamantane-resistant strains of virus. These drug-resistant influenza viruses may be useful for detailed studies of the mode of action of aminoadamantane.
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/4515875-13725919,
http://linkedlifedata.com/resource/pubmed/commentcorrection/4515875-13769274,
http://linkedlifedata.com/resource/pubmed/commentcorrection/4515875-14240407,
http://linkedlifedata.com/resource/pubmed/commentcorrection/4515875-16562058,
http://linkedlifedata.com/resource/pubmed/commentcorrection/4515875-4102573,
http://linkedlifedata.com/resource/pubmed/commentcorrection/4515875-4104457,
http://linkedlifedata.com/resource/pubmed/commentcorrection/4515875-4111024,
http://linkedlifedata.com/resource/pubmed/commentcorrection/4515875-4285582,
http://linkedlifedata.com/resource/pubmed/commentcorrection/4515875-4877518,
http://linkedlifedata.com/resource/pubmed/commentcorrection/4515875-5434369,
http://linkedlifedata.com/resource/pubmed/commentcorrection/4515875-5781863,
http://linkedlifedata.com/resource/pubmed/commentcorrection/4515875-5782109
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Jun
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pubmed:issn |
0022-1724
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
71
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
227-36
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pubmed:dateRevised |
2010-9-10
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pubmed:meshHeading |
pubmed-meshheading:4515875-Amantadine,
pubmed-meshheading:4515875-Animals,
pubmed-meshheading:4515875-Antigens, Viral,
pubmed-meshheading:4515875-Centrifugation, Density Gradient,
pubmed-meshheading:4515875-Densitometry,
pubmed-meshheading:4515875-Drug Resistance, Microbial,
pubmed-meshheading:4515875-Hemadsorption Inhibition Tests,
pubmed-meshheading:4515875-Lung Diseases,
pubmed-meshheading:4515875-Mice,
pubmed-meshheading:4515875-Orthomyxoviridae,
pubmed-meshheading:4515875-Serotyping
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pubmed:year |
1973
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pubmed:articleTitle |
Aminoadamantane-resistant strains of influenza A2 virus.
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pubmed:publicationType |
Journal Article
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