Linked Life Data

4514986

Source:http://linkedlifedata.com/resource/pubmed/id/4514986

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
3
pubmed:dateCreated
1973-9-4
pubmed:abstractText
The conventional formulas for genotype frequencies in a hybrid population H produced by interbreeding from ancestral populations P(1) and P(2) involve only one hybrid parameter M, equal to the fraction of alleles derived from P(2). For the one-parameter model to be accurate, all individuals of H must have probabilities for alleles determined by one and the same M. When H contains subpopulations that have different values of M, the correct genotype frequencies can be predicted by use of two parameters: (i) M(H), the average of M for all individuals of H and (ii) eta(H), defined like the eta devised by C. A. B. Smith for testing the Hardy-Weinberg Law and computed with a formula like G. R. Price's eta, which involves assortative mating covariance-in this case for the M values of the parents of H. If parents of H have equal average M values for males and females, and mate at random, eta(H) vanishes. For perfect assortative mating, eta(H) is the variance of M for H. As for Smith's eta, eta(H) provides a test of fit of prediction to observed that is sensitive to signs of deviations. Using eta(H) with T. E. Reed's data for Gm in Oakland, California Negroes, his one-parameter fit ("good" by his chi-square test) is significantly rejected (P = 0.04). A simultaneous good fit of Reed's Gm data and his Duffy data results (chi-square, 1 df = 0.88, P > 0.30) from the use of previously published values of 0.23 and 0.047 for M(H) and eta(H). It is concluded that Reed's conclusion that these values were in error is itself in error, as is also his view that differences between M values from different genes and deviations from frequencies expected within genes are not likely to give significant information about variance of M.
pubmed:commentsCorrections
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:status
MEDLINE
pubmed:month
Mar
pubmed:issn
0027-8424
pubmed:author
pubmed:issnType
Print
pubmed:volume
70
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
732-6
pubmed:dateRevised
2009-11-18
pubmed:meshHeading
pubmed:year
1973
pubmed:articleTitle
Deviations from Hardy-Weinberg frequencies caused by assortative mating in hybrid populations.
pubmed:publicationType
Journal Article