Linked Life Data

451337

Source:http://linkedlifedata.com/resource/pubmed/id/451337

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
3
pubmed:dateCreated
1979-8-16
pubmed:abstractText
Pretreatment of mouse skin in vivo with indomethacin prevents the stimulation of epidermal cell proliferation caused by either removal of the horny layer or by application of phorbol ester TPA. The stimulatory effect of phorbol ester "TI8" is only partially inhibited, whereas the drug indomethacin has no effect on the proliferative response to skin massage or the hyperplasiogenic reaction induced by phorbol ester 4-0-methyl-TPA. These results show that depending on the stimulus, epidermal cell proliferation and hyperplasia can proceed either via an indomethacin sensitive or via an indomethacin insensitive pathway, and that indomethacin sensitivity is neither related to the hyperplasiogenic nor the tumor-promoting efficiency of the stimulus. Although TPA and 4-0-methyl-TPA are structurally closely related phorbol esters, they have different mechanisms of mitogenic action.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Jun
pubmed:issn
0034-5164
pubmed:author
pubmed:issnType
Print
pubmed:volume
24
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
533-41
pubmed:dateRevised
2003-11-14
pubmed:meshHeading
pubmed:year
1979
pubmed:articleTitle
The effect of indomethacin on cell proliferation induced by chemical and mechanical means in mouse epidermis in vivo.
pubmed:publicationType
Journal Article