Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
1
pubmed:dateCreated
1973-3-15
pubmed:abstractText
Thyroid hormone administered in vivo increased carrier-mediated (atractyloside-sensitive) ADP uptake by rat liver mitochondria. 3 Days after a single large dose of triiodothyronine (20 mug/100 g of body weight), mitochondrial uptake of ADP measured at 6 degrees was 2.35 +/- 0.17 nmol/min per mg of protein, compared with an uptake of 1.81 +/- 0.19 nmol/min per mg of protein in mitochondria from untreated rats (P < 0.025). Cyanide (1.33 mM) had no effect on ADP uptake by mitochondria from either untreated or triiodothyronine-treated animals. Uptake of ADP by mitochondria from thyroidectomized rats treated with thyroxine for 7 days was 2.89 +/- 0.40 nmol/min per mg in mitochondria from thyrotoxic rats (20 mug of thyroxine per 100 g per day) and 1.98 +/- 0.22 nmol/min per mg in mitochondria from euthyroid rats (2 mug of thyroxine per 100 g per day) (P < 0.025). Mitochondria from both untreated and thyroid hormone-treated rats displayed a highly significant linear correlation between ADP uptake and ADP-dependent (i.e., state 3 minus state 4) oxygen consumption. There was, however, no difference in respiratory control ratios between mitochondria from euthyroid and thyrotoxic animals. Administration of dinitrophenol (2 mg/100 g) also stimulated carrier-mediated ADP uptake, but respiratory control of mitochondria from dinitrophenol-treated animals was virtually abolished. Triiodothyronine in vitro, at concentrations of 100 and 0.1 nM, appeared to inhibit rather than stimulate the uptake of mitochondrial ADP. The relationship between these observations and the clinical manifestations of thyrotoxicosis is discussed from the point of view of the possible effects of increased mitochondrial ADP transport on oxidative phosphorylation and adenosyl nucleotide metabolism.
pubmed:commentsCorrections
http://linkedlifedata.com/resource/pubmed/commentcorrection/4509666-13313307, http://linkedlifedata.com/resource/pubmed/commentcorrection/4509666-13907896, http://linkedlifedata.com/resource/pubmed/commentcorrection/4509666-13954890, http://linkedlifedata.com/resource/pubmed/commentcorrection/4509666-13993432, http://linkedlifedata.com/resource/pubmed/commentcorrection/4509666-14284758, http://linkedlifedata.com/resource/pubmed/commentcorrection/4509666-14445661, http://linkedlifedata.com/resource/pubmed/commentcorrection/4509666-4231908, http://linkedlifedata.com/resource/pubmed/commentcorrection/4509666-4252666, http://linkedlifedata.com/resource/pubmed/commentcorrection/4509666-4291074, http://linkedlifedata.com/resource/pubmed/commentcorrection/4509666-4966963, http://linkedlifedata.com/resource/pubmed/commentcorrection/4509666-4972613, http://linkedlifedata.com/resource/pubmed/commentcorrection/4509666-5289002, http://linkedlifedata.com/resource/pubmed/commentcorrection/4509666-5499232, http://linkedlifedata.com/resource/pubmed/commentcorrection/4509666-5499233, http://linkedlifedata.com/resource/pubmed/commentcorrection/4509666-5632204, http://linkedlifedata.com/resource/pubmed/commentcorrection/4509666-5725814, http://linkedlifedata.com/resource/pubmed/commentcorrection/4509666-5759704, http://linkedlifedata.com/resource/pubmed/commentcorrection/4509666-5939933
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Jan
pubmed:issn
0027-8424
pubmed:author
pubmed:issnType
Print
pubmed:volume
70
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
98-102
pubmed:dateRevised
2009-11-18
pubmed:meshHeading
pubmed:year
1973
pubmed:articleTitle
Stimulation of mitochondrial adenosine diphosphate uptake by thyroid hormones.
pubmed:publicationType
Journal Article