Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
2
pubmed:dateCreated
1972-4-26
pubmed:abstractText
Virus-specific RNA was isolated from cells transformed by human adenovirus 2 and 7 by multiple hybridizations with and elutions from homologous viral DNA; RNA molecules purified by this selection procedure hybridized efficiently with both viral DNA (24-50%) and DNA from untransformed cells (12-27%). Virus-specific RNA isolated in the same manner from cells productively infected with adenoviruses did not hybridize significantly with cellular DNA. These findings suggest that RNA molecules containing covalently-linked viral and cellular sequences are transcribed in cells transformed by human adenoviruses. The high efficiency of hybridization with DNA from untransformed cells implies that viral DNA is integrated adjacent to highly reiterated cellular DNA sequences.
pubmed:commentsCorrections
http://linkedlifedata.com/resource/pubmed/commentcorrection/4501122-13950097, http://linkedlifedata.com/resource/pubmed/commentcorrection/4501122-14215651, http://linkedlifedata.com/resource/pubmed/commentcorrection/4501122-4299269, http://linkedlifedata.com/resource/pubmed/commentcorrection/4501122-4328252, http://linkedlifedata.com/resource/pubmed/commentcorrection/4501122-4874239, http://linkedlifedata.com/resource/pubmed/commentcorrection/4501122-4920471, http://linkedlifedata.com/resource/pubmed/commentcorrection/4501122-5165249, http://linkedlifedata.com/resource/pubmed/commentcorrection/4501122-5227675, http://linkedlifedata.com/resource/pubmed/commentcorrection/4501122-5263008, http://linkedlifedata.com/resource/pubmed/commentcorrection/4501122-5263771, http://linkedlifedata.com/resource/pubmed/commentcorrection/4501122-5636880, http://linkedlifedata.com/resource/pubmed/commentcorrection/4501122-5808220, http://linkedlifedata.com/resource/pubmed/commentcorrection/4501122-5969070
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Feb
pubmed:issn
0027-8424
pubmed:author
pubmed:issnType
Print
pubmed:volume
69
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
427-30
pubmed:dateRevised
2009-11-18
pubmed:meshHeading
pubmed:year
1972
pubmed:articleTitle
The mechanism of viral carcinogenesis by DNA mammalian viruses: RNA transcripts containing viral and highly reiterated cellular base sequences in adenovirus-transformed cells (DNA-RNA hybridization-viral-cell mRNA).
pubmed:publicationType
Journal Article