Linked Life Data

446876

Source:http://linkedlifedata.com/resource/pubmed/id/446876

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
1
pubmed:dateCreated
1979-8-29
pubmed:abstractText
An androgen-responsive cell strain of chick-comb fibroblasts has been established in culture. Cells were obtained from combs of 1--2 day old white Leghorn cockerels and cultured in Dulbecco's modified Eagle medium supplemented with 10% fetal calf serum and 6 g/l glucose. The cells required serum but not androgens for growth. In the presence of androgens, growth rate and incorporation of labeled precursors into protein and RNA were markedly increased in exponentially growing cells, but not in confluent cultures. Androgens exerted these stimulatory effects in a dose-dependent fashion. It is concluded that chick-comb fibroblasts, which respond to androgens in vivo, retain this responsiveness when cultured. They furnish a well-defined system of potential value for studies of the molecular mechanisms of androgen action.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Jan
pubmed:issn
0303-7207
pubmed:author
pubmed:issnType
Print
pubmed:volume
13
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
35-45
pubmed:dateRevised
2004-11-17
pubmed:meshHeading
pubmed:year
1979
pubmed:articleTitle
Chick-comb fibroblasts. A new strain of cultured cells sensitive to androgens.
pubmed:publicationType
Journal Article