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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
3
|
| pubmed:dateCreated |
1979-8-16
|
| pubmed:abstractText |
Release of endogenous somatostatin (SRIF) from the rat cerebral cortical slices incubated in Krebs-bicarbonate buffer was increased from the basal rate of 3.4 +/- 0.6% of the total SRIF content in 15 min at [K+]o = 5.6 mM, to 13.1 +/- 1.6% upon raising the [K+]o to 56.6 mM. The high-K+ evoked SRIF release was absent when Ca++ in the medium was replaced by Mn++. The isolated synaptosomes from rat cerebral cortex contain 13.2 +/- 3.1 ng SRIF/mg protein compared to 0.33 +/- 0.01 ng/mg protein in the cortical tissue as a whole, suggesting that nerve terminals are the main source of the peptide released upon membrane depolarization.
|
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:chemical | |
| pubmed:status |
MEDLINE
|
| pubmed:month |
Mar
|
| pubmed:issn |
0014-4754
|
| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:day |
15
|
| pubmed:volume |
35
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
351-2
|
| pubmed:dateRevised |
2003-11-14
|
| pubmed:meshHeading |
pubmed-meshheading:446613-Animals,
pubmed-meshheading:446613-Cerebral Cortex,
pubmed-meshheading:446613-Dose-Response Relationship, Drug,
pubmed-meshheading:446613-Kinetics,
pubmed-meshheading:446613-Male,
pubmed-meshheading:446613-Potassium,
pubmed-meshheading:446613-Rats,
pubmed-meshheading:446613-Somatostatin,
pubmed-meshheading:446613-Synaptosomes
|
| pubmed:year |
1979
|
| pubmed:articleTitle |
High K+-induced release of somatostatin from the cortical preparation of rat brain.
|
| pubmed:publicationType |
Journal Article
|