| pubmed-article:4455202 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:4455202 | lifeskim:mentions | umls-concept:C0314875 | lld:lifeskim |
| pubmed-article:4455202 | lifeskim:mentions | umls-concept:C0030958 | lld:lifeskim |
| pubmed-article:4455202 | lifeskim:mentions | umls-concept:C0004599 | lld:lifeskim |
| pubmed-article:4455202 | lifeskim:mentions | umls-concept:C0026458 | lld:lifeskim |
| pubmed-article:4455202 | lifeskim:mentions | umls-concept:C0042313 | lld:lifeskim |
| pubmed-article:4455202 | lifeskim:mentions | umls-concept:C1280500 | lld:lifeskim |
| pubmed-article:4455202 | lifeskim:mentions | umls-concept:C0596988 | lld:lifeskim |
| pubmed-article:4455202 | lifeskim:mentions | umls-concept:C0220781 | lld:lifeskim |
| pubmed-article:4455202 | lifeskim:mentions | umls-concept:C1883254 | lld:lifeskim |
| pubmed-article:4455202 | pubmed:issue | 1 | lld:pubmed |
| pubmed-article:4455202 | pubmed:dateCreated | 1975-5-29 | lld:pubmed |
| pubmed-article:4455202 | pubmed:abstractText | The synthesis of peptidoglycan by cell-free membrane and membrane+wall preparations from an autolysin-deficient, beta-lactamase-negative mutant of Bacillus licheniformis N.C.T.C. 6346 was studied. The membrane preparation synthesized un-cross-linked polymer, the formation of which was not inhibited by beta-lactam antibiotics. Release of d-alanine by the action of d-alanine carboxypeptidase was inhibited variably according to the antibiotic. This inhibition was reversed by neutral hydroxylamine but not by the action of beta-lactamases or by washing. Bacitracin inhibited peptidoglycan synthesis, but not the d-alanine carboxypeptidase. Examination of peptidoglycan synthesized in the presence of excess of bacitracin showed that synthesis was not restricted to the addition of one disaccharide-pentapeptide unit at each synthetic site, an average of 2-3 disaccharide-pentapeptide units being added. Peptidoglycan synthesis was three- to four-fold more sensitive to vancomycin than was the release of d-alanine by the action of the carboxypeptidase. Incorporation of newly synthesized peptidoglycan into pre-existing cell wall was studied in membrane+wall preparations. This incorporation was catalysed by a benzylpenicillin- and cephaloridine-sensitive transpeptidase. The concentrations of these antibiotics giving 50% inhibition of incorporation were almost identical with those required to inhibit growth of the bacillus. Inhibition of the transpeptidase was reversed by treatment with beta-lactamase or by washing. | lld:pubmed |
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| pubmed-article:4455202 | pubmed:language | eng | lld:pubmed |
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| pubmed-article:4455202 | pubmed:citationSubset | IM | lld:pubmed |
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| pubmed-article:4455202 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:4455202 | pubmed:month | Jul | lld:pubmed |
| pubmed-article:4455202 | pubmed:issn | 0264-6021 | lld:pubmed |
| pubmed-article:4455202 | pubmed:author | pubmed-author:WardJ BJB | lld:pubmed |
| pubmed-article:4455202 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:4455202 | pubmed:volume | 141 | lld:pubmed |
| pubmed-article:4455202 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:4455202 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:4455202 | pubmed:pagination | 227-41 | lld:pubmed |
| pubmed-article:4455202 | pubmed:dateRevised | 2010-9-13 | lld:pubmed |
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| pubmed-article:4455202 | pubmed:year | 1974 | lld:pubmed |
| pubmed-article:4455202 | pubmed:articleTitle | The synthesis of peptidoglycan in an autolysin-deficient mutant of Bacillus licheniformis N.C.T.C. 6346 and the effect of beta-lactam antibiotics, bacitracin and vancomycin. | lld:pubmed |
| pubmed-article:4455202 | pubmed:publicationType | Journal Article | lld:pubmed |
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