Linked Life Data

445303

Source:http://linkedlifedata.com/resource/pubmed/id/445303

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
9
pubmed:dateCreated
1979-8-29
pubmed:abstractText
In a group of patients with clinically diagnosed drug hypersensitivity the in vitro lymphocyte response to the suspected drug was assessed by the lymphocyte transformation test. The test gave positive results in all 15 patients with penicillin-induced immediate or accelerated allergic reactions and positive immediate skin-test reactivity to the major or the minor antigenic determinant of penicillin, or both, but in only 3 of the 12 patients with delayed-onset maculopapular rashes induced by penicillin, despite positive immediate reactivity to the skin-test reagents.Lymphocyte stimulation greater than five times the control level was demonstrated for five patients with penicillin-induced erythroderma, Stevens-Johnson syndrome or a serum-sickness-like illness, or with methicillin-induced interstitial nephritis, all of whom had negative reactions to the appropriate skin-test reagents. A low level of stimulation was seen in eight other skin-test-negative patients with possible allergic reactions induced by penicillins. However, in all subjects tested the stimulation was significantly greater than the mean for control subjects.For 9 of 11 patients with isoniazid-induced hepatitis or maculopapular rashes, but for only 8 of 31 patients with eruptions induced by a variety of drugs other than penicillins and isoniazid, significant stimulation occurred in the lymphocyte transformation test.It is concluded that the lymphocyte transformation test is useful in the detection of hypersensitivity to the penicillins (although in IgE-mediated reactions skin testing is clearly preferable) and isoniazid but is of limited value in the demonstration of hypersensitivity to other drugs.
pubmed:commentsCorrections
http://linkedlifedata.com/resource/pubmed/commentcorrection/445303-239125, http://linkedlifedata.com/resource/pubmed/commentcorrection/445303-4117852, http://linkedlifedata.com/resource/pubmed/commentcorrection/445303-4137237, http://linkedlifedata.com/resource/pubmed/commentcorrection/445303-4139131, http://linkedlifedata.com/resource/pubmed/commentcorrection/445303-4187114, http://linkedlifedata.com/resource/pubmed/commentcorrection/445303-4274095, http://linkedlifedata.com/resource/pubmed/commentcorrection/445303-4993767, http://linkedlifedata.com/resource/pubmed/commentcorrection/445303-5080721, http://linkedlifedata.com/resource/pubmed/commentcorrection/445303-5105391, http://linkedlifedata.com/resource/pubmed/commentcorrection/445303-5231430, http://linkedlifedata.com/resource/pubmed/commentcorrection/445303-5251662, http://linkedlifedata.com/resource/pubmed/commentcorrection/445303-5359962, http://linkedlifedata.com/resource/pubmed/commentcorrection/445303-5781774, http://linkedlifedata.com/resource/pubmed/commentcorrection/445303-5809808, http://linkedlifedata.com/resource/pubmed/commentcorrection/445303-837643
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
AIM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
May
pubmed:issn
0008-4409
pubmed:author
pubmed:issnType
Print
pubmed:day
5
pubmed:volume
120
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
1089-94
pubmed:dateRevised
2010-6-22
pubmed:meshHeading
pubmed:year
1979
pubmed:articleTitle
Lymphocyte transformation studies in drug hypersensitivity.
pubmed:publicationType
Journal Article