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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
3
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pubmed:dateCreated |
1975-6-12
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pubmed:abstractText |
1 In conscious unrestrained cats noradrenaline, alpha-methylnoradrenaline and clonidine, infused into the lateral cerebral ventricles (i.c.v.) caused dose-related falls in blood pressure and heart rate; both effects were abolished after i.c.v. phentolamine.2 In 12 out of 20 cats, i.c.v. isoprenaline and salbutamol when given caused dose-related pressor responses and tachycardias. These effects were abolished after i.c.v. beta-adrenoceptor blocking drugs but were unaffected by alpha-adrenoceptor blocking agents.3 In 5 out of 20 cats, i.c.v. isoprenaline regularly produced dose-related falls in blood pressure with associated tachycardias; both effects were abolished after i.c.v. beta-adrenoceptor blocking agents.4 Intracerebroventricular dopamine produced cardiovascular responses which were qualitatively similar to those produced by i.c.v. isoprenaline.5 Intracerebroventricular adrenaline produced complex responses in untreated animals but typical alpha-effects were obtained after prior i.c.v. treatment with a beta-adrenoceptor blocking agent and typical beta-effects after i.c.v. pretreatment with an alpha-adrenoceptor blocking agent.6 The cardiovascular changes produced by i.c.v. beta-adrenoceptor agonists were abolished after systemic administration of hexamethonium or bethanidine.7 The results are discussed in the light of the mode of action of beta-adrenoceptor stimulants and beta-adrenoceptor blocking agents in the treatment of hypertension.
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/4451747-13773844,
http://linkedlifedata.com/resource/pubmed/commentcorrection/4451747-14434161,
http://linkedlifedata.com/resource/pubmed/commentcorrection/4451747-4112366,
http://linkedlifedata.com/resource/pubmed/commentcorrection/4451747-4144485,
http://linkedlifedata.com/resource/pubmed/commentcorrection/4451747-4144872,
http://linkedlifedata.com/resource/pubmed/commentcorrection/4451747-4146560,
http://linkedlifedata.com/resource/pubmed/commentcorrection/4451747-4196583,
http://linkedlifedata.com/resource/pubmed/commentcorrection/4451747-4382488,
http://linkedlifedata.com/resource/pubmed/commentcorrection/4451747-4386523,
http://linkedlifedata.com/resource/pubmed/commentcorrection/4451747-4396661,
http://linkedlifedata.com/resource/pubmed/commentcorrection/4451747-4402101,
http://linkedlifedata.com/resource/pubmed/commentcorrection/4451747-4402797,
http://linkedlifedata.com/resource/pubmed/commentcorrection/4451747-4511839,
http://linkedlifedata.com/resource/pubmed/commentcorrection/4451747-4733743,
http://linkedlifedata.com/resource/pubmed/commentcorrection/4451747-4894830,
http://linkedlifedata.com/resource/pubmed/commentcorrection/4451747-5041485,
http://linkedlifedata.com/resource/pubmed/commentcorrection/4451747-5085233,
http://linkedlifedata.com/resource/pubmed/commentcorrection/4451747-5160448,
http://linkedlifedata.com/resource/pubmed/commentcorrection/4451747-5259359,
http://linkedlifedata.com/resource/pubmed/commentcorrection/4451747-5469791,
http://linkedlifedata.com/resource/pubmed/commentcorrection/4451747-5575577,
http://linkedlifedata.com/resource/pubmed/commentcorrection/4451747-5654157,
http://linkedlifedata.com/resource/pubmed/commentcorrection/4451747-5969207
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Albuterol,
http://linkedlifedata.com/resource/pubmed/chemical/Alprenolol,
http://linkedlifedata.com/resource/pubmed/chemical/Atropine,
http://linkedlifedata.com/resource/pubmed/chemical/Clonidine,
http://linkedlifedata.com/resource/pubmed/chemical/Epinephrine,
http://linkedlifedata.com/resource/pubmed/chemical/Hexamethonium Compounds,
http://linkedlifedata.com/resource/pubmed/chemical/Isoproterenol,
http://linkedlifedata.com/resource/pubmed/chemical/Lidocaine,
http://linkedlifedata.com/resource/pubmed/chemical/Norepinephrine,
http://linkedlifedata.com/resource/pubmed/chemical/Pempidine,
http://linkedlifedata.com/resource/pubmed/chemical/Phentolamine,
http://linkedlifedata.com/resource/pubmed/chemical/Practolol,
http://linkedlifedata.com/resource/pubmed/chemical/Propranolol,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, Adrenergic,
http://linkedlifedata.com/resource/pubmed/chemical/Sotalol
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pubmed:status |
MEDLINE
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pubmed:month |
Jul
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pubmed:issn |
0007-1188
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
51
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
325-33
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pubmed:dateRevised |
2009-11-18
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pubmed:meshHeading |
pubmed-meshheading:4451747-Albuterol,
pubmed-meshheading:4451747-Alprenolol,
pubmed-meshheading:4451747-Animals,
pubmed-meshheading:4451747-Atropine,
pubmed-meshheading:4451747-Bethanidine,
pubmed-meshheading:4451747-Blood Pressure,
pubmed-meshheading:4451747-Cats,
pubmed-meshheading:4451747-Cerebral Ventricles,
pubmed-meshheading:4451747-Clonidine,
pubmed-meshheading:4451747-Dopamine,
pubmed-meshheading:4451747-Epinephrine,
pubmed-meshheading:4451747-Female,
pubmed-meshheading:4451747-Heart Rate,
pubmed-meshheading:4451747-Hexamethonium Compounds,
pubmed-meshheading:4451747-Injections,
pubmed-meshheading:4451747-Isoproterenol,
pubmed-meshheading:4451747-Lidocaine,
pubmed-meshheading:4451747-Male,
pubmed-meshheading:4451747-Norepinephrine,
pubmed-meshheading:4451747-Pempidine,
pubmed-meshheading:4451747-Phentolamine,
pubmed-meshheading:4451747-Practolol,
pubmed-meshheading:4451747-Propranolol,
pubmed-meshheading:4451747-Rabbits,
pubmed-meshheading:4451747-Rats,
pubmed-meshheading:4451747-Receptors, Adrenergic,
pubmed-meshheading:4451747-Sotalol,
pubmed-meshheading:4451747-Species Specificity,
pubmed-meshheading:4451747-Time Factors
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pubmed:year |
1974
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pubmed:articleTitle |
Central alpha- and beta-adrenoceptors modifying arterial blood pressure and heart rate in conscious cats.
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pubmed:publicationType |
Journal Article
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