|
pubmed:otherAbstract |
PIP: 8 nulliparous women, all approximately 15 weeks pregnant, were administered 350 ml Macrodex intraamniotically during a period of 15-30 minutes to increase uterine volume. 4 of the patients aborted following a decrease in plasma progesterone and an increase in resting pressure, active pressure, and oxytocin response. In 2 patients, plasma progesterone increased while resting pressure, active pressure, and oxytocin response did not increase, and pregnancy continued undisturbed. It is concluded that increasing uterine volume may induce a compensatory synthesis of progesterone in the palcenta provided that: 1) the osmotic action of the injected hypertonic solution does not suppress placental function to a degree equal to that of the stimulatory effect of increasing volume; 2) the osmotic increase in volume is slow enough to permit the time-dependent increase in progesteronegenesis; and 3) the increase in intrauterine pressure and clinical progress in abortion does not suppress placental endocrine function. Further experiments are necessary to verify this interpretation.
|
