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rdf:type |
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lifeskim:mentions |
umls-concept:C0003261,
umls-concept:C0021055,
umls-concept:C0205263,
umls-concept:C0301869,
umls-concept:C0348080,
umls-concept:C0542341,
umls-concept:C0560175,
umls-concept:C1517004,
umls-concept:C1704410,
umls-concept:C1706209,
umls-concept:C1948023
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pubmed:issue |
1
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pubmed:dateCreated |
1971-9-15
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pubmed:abstractText |
Administration of nonimmunogenic 2,4-dinitrophenyl (DNP) conjugates of copolymers of D or L-glutamic acid and lysine (GL) induces hapten-specific tolerance in nonimmune and DNP-ovalbumin-primed strain 13 guinea pigs. This tolerant state is evidenced by depressed anti-DNP antibody synthesis in response to challenge with DNP-ovalbumin and by a diminished frequency of DNP-specific antigen-binding cells and of anti-DNP antibody-secreting cells. Such a nonimmunogenic compound (DNP-D-GL) will nevertheless elicit a DNP-specific anamnestic antibody response when administered at an appropriate time to DNP-ovalbumin-primed guinea pigs undergoing a graft-versus-host reaction. These experiments are discussed in terms of a two-cell theory of stimulation of antibody responses.
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/4397662-13510545,
http://linkedlifedata.com/resource/pubmed/commentcorrection/4397662-13867017,
http://linkedlifedata.com/resource/pubmed/commentcorrection/4397662-13957684,
http://linkedlifedata.com/resource/pubmed/commentcorrection/4397662-14076917,
http://linkedlifedata.com/resource/pubmed/commentcorrection/4397662-14112273,
http://linkedlifedata.com/resource/pubmed/commentcorrection/4397662-14169108,
http://linkedlifedata.com/resource/pubmed/commentcorrection/4397662-14193158,
http://linkedlifedata.com/resource/pubmed/commentcorrection/4397662-14265884,
http://linkedlifedata.com/resource/pubmed/commentcorrection/4397662-4100380,
http://linkedlifedata.com/resource/pubmed/commentcorrection/4397662-4101344,
http://linkedlifedata.com/resource/pubmed/commentcorrection/4397662-4101345,
http://linkedlifedata.com/resource/pubmed/commentcorrection/4397662-4109111,
http://linkedlifedata.com/resource/pubmed/commentcorrection/4397662-4110123,
http://linkedlifedata.com/resource/pubmed/commentcorrection/4397662-4171394,
http://linkedlifedata.com/resource/pubmed/commentcorrection/4397662-4181830,
http://linkedlifedata.com/resource/pubmed/commentcorrection/4397662-4192271,
http://linkedlifedata.com/resource/pubmed/commentcorrection/4397662-4192295,
http://linkedlifedata.com/resource/pubmed/commentcorrection/4397662-4196067,
http://linkedlifedata.com/resource/pubmed/commentcorrection/4397662-4394909,
http://linkedlifedata.com/resource/pubmed/commentcorrection/4397662-4873344,
http://linkedlifedata.com/resource/pubmed/commentcorrection/4397662-4908392,
http://linkedlifedata.com/resource/pubmed/commentcorrection/4397662-4919143,
http://linkedlifedata.com/resource/pubmed/commentcorrection/4397662-4927594,
http://linkedlifedata.com/resource/pubmed/commentcorrection/4397662-4945475,
http://linkedlifedata.com/resource/pubmed/commentcorrection/4397662-4945476,
http://linkedlifedata.com/resource/pubmed/commentcorrection/4397662-4945477,
http://linkedlifedata.com/resource/pubmed/commentcorrection/4397662-4979775,
http://linkedlifedata.com/resource/pubmed/commentcorrection/4397662-5099924,
http://linkedlifedata.com/resource/pubmed/commentcorrection/4397662-5355110,
http://linkedlifedata.com/resource/pubmed/commentcorrection/4397662-5691986,
http://linkedlifedata.com/resource/pubmed/commentcorrection/4397662-5917547,
http://linkedlifedata.com/resource/pubmed/commentcorrection/4397662-5938816,
http://linkedlifedata.com/resource/pubmed/commentcorrection/4397662-6023661,
http://linkedlifedata.com/resource/pubmed/commentcorrection/4397662-6027783
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
AIM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Jul
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pubmed:issn |
0022-1007
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:day |
1
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pubmed:volume |
134
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
201-23
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pubmed:dateRevised |
2010-6-22
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pubmed:meshHeading |
pubmed-meshheading:4397662-Animals,
pubmed-meshheading:4397662-Antibodies,
pubmed-meshheading:4397662-Antibody Formation,
pubmed-meshheading:4397662-Antibody Specificity,
pubmed-meshheading:4397662-Antibody-Producing Cells,
pubmed-meshheading:4397662-Autoradiography,
pubmed-meshheading:4397662-Bone Marrow,
pubmed-meshheading:4397662-Bone Marrow Cells,
pubmed-meshheading:4397662-Dinitrophenols,
pubmed-meshheading:4397662-Glutamates,
pubmed-meshheading:4397662-Graft vs Host Reaction,
pubmed-meshheading:4397662-Guinea Pigs,
pubmed-meshheading:4397662-Haptens,
pubmed-meshheading:4397662-Immune Tolerance,
pubmed-meshheading:4397662-Immunity, Cellular,
pubmed-meshheading:4397662-Immunization, Passive,
pubmed-meshheading:4397662-Iodine Isotopes,
pubmed-meshheading:4397662-Lysine,
pubmed-meshheading:4397662-Ovalbumin,
pubmed-meshheading:4397662-Thymus Gland
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pubmed:year |
1971
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pubmed:articleTitle |
Carrier function in anti-hapten antibody responses. IV. Experimental conditions for the induction of hapten-specific tolerance or for the stimulation of anti-hapten anamnestic responses by "nonimmunogenic" hapten-polypeptide conjugates.
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pubmed:publicationType |
Journal Article
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