Linked Life Data

4396971

Source:http://linkedlifedata.com/resource/pubmed/id/4396971

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
3
pubmed:dateCreated
1971-7-6
pubmed:abstractText
1. After intravenous injection of practolol the blood concentration-time curve is fitted by a bi-exponential function. A two compartment open system model is therefore a minimal requirement in order to describe adequately the distribution of the drug in the body.2. The parameters of the two compartment model for practolol were determined. The mean values for the ;fast disposition' half life and the ;slow disposition' half life were 0.5 min and 13.3 min, respectively.3. The rate constants of distribution and elimination were similar in different animals. The volume of the central compartment was related to the weight of the animal.4. The absorption of practolol from an intestinal site was measured by its appearance in the blood. The rate constant for this process was estimated to be 0.03 min(-1).
pubmed:commentsCorrections
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Mar
pubmed:issn
0007-1188
pubmed:author
pubmed:issnType
Print
pubmed:volume
41
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
513-20
pubmed:dateRevised
2009-11-18
pubmed:meshHeading
pubmed:year
1971
pubmed:articleTitle
Distribution kinetics and intestinal absorption of practolol in the rat.
pubmed:publicationType
Journal Article