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pubmed:otherAbstract |
PIP: The in vitro effects of cortisol, estradiol, progesterone, and testosterone on the uptake of tritiated thymidine into the tumor cells of 25 women with primary or metastatic breast cancer were studied and compared with the objective clinical response to ablative endocrine surgery. A correlation between the clinical results with endocrine therapy and the in vitro assay results obtained in 23 of the 25 patients. 8 patients who did not respond to clinical endocrine therapy did not respond in vitro. A significant clinical response (p less than .05) to ablative endocrine surgery, lasting for at least 6 months, was observed in 9 of 15 patients whose tumors responded in vitro. Precise determination of the predictive capacity of the assay will require a blind prospective evaluation.
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