Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
10
pubmed:dateCreated
1975-2-6
pubmed:abstractText
Structure-function relationships for vitamin D, its metabolites, and analogs are discussed with particular emphasis on the A-ring conformation. It is emphasized that the A-ring of these seco-steroids consists of a pair of rapidly equilibrating chair conformers. As a consequence, different chair conformations produce different orientations of substituent groups in the A-ring. It is proposed that the 1alpha-hydroxyl of 1alpha,25-dihydroxyvitamin D(3) or its geometric equivalent in analogs must occupy the equatorial, as opposed to the axial, orientation for optimization of biological activity. This proposal is discussed in relation to existing published data on structure-function relationships and the steroid hormone model of action for the biologically active form of vitamin D. This three-dimensional topological model suggests the synthesis of other vitamin D analogs.
pubmed:commentsCorrections
http://linkedlifedata.com/resource/pubmed/commentcorrection/4372612-14099229, http://linkedlifedata.com/resource/pubmed/commentcorrection/4372612-4267263, http://linkedlifedata.com/resource/pubmed/commentcorrection/4372612-4310770, http://linkedlifedata.com/resource/pubmed/commentcorrection/4372612-4319631, http://linkedlifedata.com/resource/pubmed/commentcorrection/4372612-4321262, http://linkedlifedata.com/resource/pubmed/commentcorrection/4372612-4323845, http://linkedlifedata.com/resource/pubmed/commentcorrection/4372612-4325104, http://linkedlifedata.com/resource/pubmed/commentcorrection/4372612-4327385, http://linkedlifedata.com/resource/pubmed/commentcorrection/4372612-4330040, http://linkedlifedata.com/resource/pubmed/commentcorrection/4372612-4333142, http://linkedlifedata.com/resource/pubmed/commentcorrection/4372612-4339881, http://linkedlifedata.com/resource/pubmed/commentcorrection/4372612-4341345, http://linkedlifedata.com/resource/pubmed/commentcorrection/4372612-4341503, http://linkedlifedata.com/resource/pubmed/commentcorrection/4372612-4342432, http://linkedlifedata.com/resource/pubmed/commentcorrection/4372612-4344036, http://linkedlifedata.com/resource/pubmed/commentcorrection/4372612-4348463, http://linkedlifedata.com/resource/pubmed/commentcorrection/4372612-4348493, http://linkedlifedata.com/resource/pubmed/commentcorrection/4372612-4358418, http://linkedlifedata.com/resource/pubmed/commentcorrection/4372612-4365368, http://linkedlifedata.com/resource/pubmed/commentcorrection/4372612-4379720, http://linkedlifedata.com/resource/pubmed/commentcorrection/4372612-4384369, http://linkedlifedata.com/resource/pubmed/commentcorrection/4372612-4395012, http://linkedlifedata.com/resource/pubmed/commentcorrection/4372612-4601888, http://linkedlifedata.com/resource/pubmed/commentcorrection/4372612-4706686, http://linkedlifedata.com/resource/pubmed/commentcorrection/4372612-4744903, http://linkedlifedata.com/resource/pubmed/commentcorrection/4372612-4758912, http://linkedlifedata.com/resource/pubmed/commentcorrection/4372612-4777332, http://linkedlifedata.com/resource/pubmed/commentcorrection/4372612-4902947, http://linkedlifedata.com/resource/pubmed/commentcorrection/4372612-4933311, http://linkedlifedata.com/resource/pubmed/commentcorrection/4372612-5311514, http://linkedlifedata.com/resource/pubmed/commentcorrection/4372612-5439031, http://linkedlifedata.com/resource/pubmed/commentcorrection/4372612-5696629
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Oct
pubmed:issn
0027-8424
pubmed:author
pubmed:issnType
Print
pubmed:volume
71
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
4194-7
pubmed:dateRevised
2009-11-18
pubmed:meshHeading
pubmed:year
1974
pubmed:articleTitle
Vitamin D: concerning the relationship between molecular topology and biological function.
pubmed:publicationType
Journal Article