Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
2
pubmed:dateCreated
1974-10-4
pubmed:abstractText
Neuraminidase free of proteolytic activity substantially reduced the infectivity of vesicular stomatitis (VS) virus but less effectively than trypsin. The only sugar residue hydrolyzed by neuraminidase was N-acetyl neuraminic acid, approximately 89% of which was liberated from virion glycoprotein and the rest from virion glycolipid. Desialylation of virion glycoprotein but not of glycolipid resulted in progressive loss of infectivity. Sialyl transferase prepared and partially purified from BHK-21 cells catalyzed resialylation by CMP-[(14)C]sialic acid of the glycoprotein of neuraminidase-treated VS virions and supersialylation of unhydrolyzed VS viral glycoprotein. Resialylation of desialylated VS virions resulted in substantial (26-fold) restoration of their infectivity. We conclude that terminal neuraminic acids of VS viral sialoglycoprotein play an important role in initiation of infection with this virus.
pubmed:commentsCorrections
http://linkedlifedata.com/resource/pubmed/commentcorrection/4367903-13672998, http://linkedlifedata.com/resource/pubmed/commentcorrection/4367903-13778430, http://linkedlifedata.com/resource/pubmed/commentcorrection/4367903-14056363, http://linkedlifedata.com/resource/pubmed/commentcorrection/4367903-14907713, http://linkedlifedata.com/resource/pubmed/commentcorrection/4367903-4108932, http://linkedlifedata.com/resource/pubmed/commentcorrection/4367903-4118869, http://linkedlifedata.com/resource/pubmed/commentcorrection/4367903-4298711, http://linkedlifedata.com/resource/pubmed/commentcorrection/4367903-4307904, http://linkedlifedata.com/resource/pubmed/commentcorrection/4367903-4309923, http://linkedlifedata.com/resource/pubmed/commentcorrection/4367903-4315954, http://linkedlifedata.com/resource/pubmed/commentcorrection/4367903-4320586, http://linkedlifedata.com/resource/pubmed/commentcorrection/4367903-4322870, http://linkedlifedata.com/resource/pubmed/commentcorrection/4367903-4323714, http://linkedlifedata.com/resource/pubmed/commentcorrection/4367903-4323715, http://linkedlifedata.com/resource/pubmed/commentcorrection/4367903-4332145, http://linkedlifedata.com/resource/pubmed/commentcorrection/4367903-4342247, http://linkedlifedata.com/resource/pubmed/commentcorrection/4367903-4345495, http://linkedlifedata.com/resource/pubmed/commentcorrection/4367903-4357510, http://linkedlifedata.com/resource/pubmed/commentcorrection/4367903-4359419, http://linkedlifedata.com/resource/pubmed/commentcorrection/4367903-4889948, http://linkedlifedata.com/resource/pubmed/commentcorrection/4367903-4899474, http://linkedlifedata.com/resource/pubmed/commentcorrection/4367903-5102426, http://linkedlifedata.com/resource/pubmed/commentcorrection/4367903-5418165
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Aug
pubmed:issn
0022-538X
pubmed:author
pubmed:issnType
Print
pubmed:volume
14
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
270-81
pubmed:dateRevised
2009-11-18
pubmed:meshHeading
pubmed:year
1974
pubmed:articleTitle
Sialoglycoprotein of vesicular stomatitis virus: role of the neuraminic acid in infection.
pubmed:publicationType
Journal Article