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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
12
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pubmed:dateCreated |
1974-2-13
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pubmed:abstractText |
A colony of transformed cells was isolated from chick-embryo cells infected with a stock of nondefective Schmidt-Ruppin strain of Rous sarcoma virus. The virus recovered from this colony was a stable defective mutant very similar to the Bryan strain of Rous sarcoma virus in the following characteristics: (i) noninfectiousness of virus particles released from transformed cells that lack helper factor; (ii) formation of infectious pseudotypes by coinfection with avian leukosis virus or by interaction with endogenous-helper factor in chicken cells; (iii) ability of the noninfectious form of virus to transform chick-embryo cells in the presence of ultraviolet light-inactivated Sendai virus; (iv) absence of glycoprotein in the noninfectious form; (v) failure to produce nondefective virus by recombination with avian leukosis virus; and (vi) segregation of polymerase-negative virus. The morphology of transformed cells is characteristic of those infected by the Schmidt-Ruppin strain. The demonstration of segregation of such a defective virus from nondefective sarcoma virus and failure to detect revertants of this mutant suggest that the deletion of some genes may be involved in this mutation.
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/4357873-11515043,
http://linkedlifedata.com/resource/pubmed/commentcorrection/4357873-13952461,
http://linkedlifedata.com/resource/pubmed/commentcorrection/4357873-4106352,
http://linkedlifedata.com/resource/pubmed/commentcorrection/4357873-4285888,
http://linkedlifedata.com/resource/pubmed/commentcorrection/4357873-4292338,
http://linkedlifedata.com/resource/pubmed/commentcorrection/4357873-4297123,
http://linkedlifedata.com/resource/pubmed/commentcorrection/4357873-4309068,
http://linkedlifedata.com/resource/pubmed/commentcorrection/4357873-4312375,
http://linkedlifedata.com/resource/pubmed/commentcorrection/4357873-4317912,
http://linkedlifedata.com/resource/pubmed/commentcorrection/4357873-4320617,
http://linkedlifedata.com/resource/pubmed/commentcorrection/4357873-4321342,
http://linkedlifedata.com/resource/pubmed/commentcorrection/4357873-4321346,
http://linkedlifedata.com/resource/pubmed/commentcorrection/4357873-4331732,
http://linkedlifedata.com/resource/pubmed/commentcorrection/4357873-4332982,
http://linkedlifedata.com/resource/pubmed/commentcorrection/4357873-4332983,
http://linkedlifedata.com/resource/pubmed/commentcorrection/4357873-4333741,
http://linkedlifedata.com/resource/pubmed/commentcorrection/4357873-4333742,
http://linkedlifedata.com/resource/pubmed/commentcorrection/4357873-4335930,
http://linkedlifedata.com/resource/pubmed/commentcorrection/4357873-4338996,
http://linkedlifedata.com/resource/pubmed/commentcorrection/4357873-4350228,
http://linkedlifedata.com/resource/pubmed/commentcorrection/4357873-5101018
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Dec
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pubmed:issn |
0027-8424
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
70
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
3493-7
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pubmed:dateRevised |
2011-11-17
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pubmed:meshHeading |
pubmed-meshheading:4357873-Amino Acids,
pubmed-meshheading:4357873-Animals,
pubmed-meshheading:4357873-Avian Sarcoma Viruses,
pubmed-meshheading:4357873-Avian leukosis virus,
pubmed-meshheading:4357873-Carbon Radioisotopes,
pubmed-meshheading:4357873-Cell Transformation, Neoplastic,
pubmed-meshheading:4357873-Cells, Cultured,
pubmed-meshheading:4357873-Chick Embryo,
pubmed-meshheading:4357873-Clone Cells,
pubmed-meshheading:4357873-Defective Viruses,
pubmed-meshheading:4357873-Electrophoresis, Polyacrylamide Gel,
pubmed-meshheading:4357873-Glucosamine,
pubmed-meshheading:4357873-Helper Viruses,
pubmed-meshheading:4357873-Molecular Weight,
pubmed-meshheading:4357873-Mutation,
pubmed-meshheading:4357873-Parainfluenza Virus 1, Human,
pubmed-meshheading:4357873-Recombination, Genetic,
pubmed-meshheading:4357873-Tritium,
pubmed-meshheading:4357873-Viral Plaque Assay,
pubmed-meshheading:4357873-Viral Proteins,
pubmed-meshheading:4357873-Virus Cultivation,
pubmed-meshheading:4357873-Virus Replication
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pubmed:year |
1973
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pubmed:articleTitle |
Isolation of defective mutant of avian sarcoma virus.
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pubmed:publicationType |
Journal Article
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