Linked Life Data

435626

Source:http://linkedlifedata.com/resource/pubmed/id/435626

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
4
pubmed:dateCreated
1979-7-16
pubmed:abstractText
Products of mouse peritoneal macrophage destruction (PMD) obtained by aseptic freezing-thawing of the cells, repeated thrice, were found to elicit in syngeneic mice injected with PMD intraperitoneally an increase of CFUs count in the hemopoietic bone marrow tissue and the spleen, as demonstrated by the Till and McCullooch technique. This proved to be a true increase since the transplatned stem cell fraction sorbed by the recipient's spleen was relatively lower in donor mice given PMD than in the control. Although PMD caused an increase of both erythropoietic (E) and granulocytopoietic-monocytic (G) colonies number, the E/G ratio was decreased; one of the mechanisms of the described effect could be the influence of PMD on the hemopoiesis-inducing microenvironment, as the same effects were obtained in mice injected repeatedly with PMD prior to the transplantation of bone marrow tissue of normal donors. Other possible mechanisms of these effects were analyzed, with consideration to the fact that in experiments with preincubation of bone marrow tissue with PMD prior to injection to the lethally irradiated mice no direct stimulating influence of PMD on the stem cell could be revealed.
pubmed:language
rus
pubmed:journal
pubmed:citationSubset
IM
pubmed:status
MEDLINE
pubmed:month
Apr
pubmed:issn
0365-9615
pubmed:author
pubmed:issnType
Print
pubmed:volume
87
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
345-7
pubmed:dateRevised
2008-10-8
pubmed:meshHeading
pubmed:year
1979
pubmed:articleTitle
[Effect of tissue macrophage destruction products on hematopoietic stem cells].
pubmed:publicationType
Journal Article, English Abstract