Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
4
pubmed:dateCreated
1973-9-4
pubmed:abstractText
Homogenates and subcellular fractions of the intimamedia of hog aorta have been prepared and examined for the presence of the enzymes catalyzing the conversion of acetyl CoA to squalene. Enzyme activities effecting the conversion of acetyl CoA to 3-hydroxy-3-methylglutarate (HMG); HMG CoA to mevalonic acid; mevalonic acid to 5-phosphomevalonic acid, 5-pyrophosphomevalonic acid, and isopentenyl pyrophosphate; isopentenyl pyrophosphate to farnesyl pyrophosphate; and farnesyl pyrophosphate to squalene have been demonstrated in these homogenates. The overall conversion of mevalonate to squalene has also been demonstrated with recombined fractions of hog aorta homogenates. Data are also presented that suggest that phosphatases present in the crude homogenates act to cleave farnesyl pyrophosphate to farnesol, and phospho- and pyrophosphomevalonate to mevalonate.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Jul
pubmed:issn
0022-2275
pubmed:author
pubmed:issnType
Print
pubmed:volume
14
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
485-94
pubmed:dateRevised
2007-3-21
pubmed:meshHeading
pubmed-meshheading:4351784-Acetyl Coenzyme A, pubmed-meshheading:4351784-Alcohol Oxidoreductases, pubmed-meshheading:4351784-Alkenes, pubmed-meshheading:4351784-Animals, pubmed-meshheading:4351784-Aorta, pubmed-meshheading:4351784-Carbon Isotopes, pubmed-meshheading:4351784-Chromatography, DEAE-Cellulose, pubmed-meshheading:4351784-Chromatography, Gas, pubmed-meshheading:4351784-Chromatography, Paper, pubmed-meshheading:4351784-Coenzyme A, pubmed-meshheading:4351784-Farnesol, pubmed-meshheading:4351784-Glutarates, pubmed-meshheading:4351784-Ligases, pubmed-meshheading:4351784-Mevalonic Acid, pubmed-meshheading:4351784-Multienzyme Complexes, pubmed-meshheading:4351784-Muscle, Smooth, pubmed-meshheading:4351784-Phosphoric Acids, pubmed-meshheading:4351784-Squalene, pubmed-meshheading:4351784-Subcellular Fractions, pubmed-meshheading:4351784-Swine
pubmed:year
1973
pubmed:articleTitle
Occurrence of the enzymes effecting the conversion of acetyl CoA to squalene in homogenates of hog aorta.
pubmed:publicationType
Journal Article