Linked Life Data

4350343

Source:http://linkedlifedata.com/resource/pubmed/id/4350343

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
2
pubmed:dateCreated
1973-7-19
pubmed:abstractText
Colicinogenic factors ColE1 and ColE2 are bacterial plasmids that exist in Escherichia coli as supercoiled deoxyribonucleic acid (DNA) and as strand-specific, relaxation complexes of supercoiled DNA and protein. Newly replicated ColE1 DNA becomes complexed with protein after the replication event. This association of DNA and protein can take place under conditions in which DNA or protein synthesis is arrested. The addition of cyclic adenosine monophosphate (c-AMP) to normal cells growing in glucose medium results in a six- to tenfold stimulation in the rate of synthesis of the protein component(s) of the complex and a three- to fivefold stimulation in the rate of ColE1 DNA replication. Employing mutants deficient in catabolite gene activator protein or adenylate cyclase, it was shown that synthesis of both the plasmid-determined protein colicin E1 and the protein component(s) of the ColE1 relaxation complex is mediated through the c-AMP-catabolite gene activator protein system. Addition of c-AMP to ColE2-containing cells results in the stimulation of synthesis of ColE2 DNA and relaxation protein(s) as well as in the production of a protein component of the ColE2 relaxation complex that renders it sensitive to induced relaxation by heat treatment. In the case of ColE2, synthesis of the relaxation protein(s) is not dependent upon catabolite gene activator protein.
pubmed:commentsCorrections
http://linkedlifedata.com/resource/pubmed/commentcorrection/4350343-14240939, http://linkedlifedata.com/resource/pubmed/commentcorrection/4350343-14284741, http://linkedlifedata.com/resource/pubmed/commentcorrection/4350343-4310317, http://linkedlifedata.com/resource/pubmed/commentcorrection/4350343-4317918, http://linkedlifedata.com/resource/pubmed/commentcorrection/4350343-4320461, http://linkedlifedata.com/resource/pubmed/commentcorrection/4350343-4327324, http://linkedlifedata.com/resource/pubmed/commentcorrection/4350343-4327512, http://linkedlifedata.com/resource/pubmed/commentcorrection/4350343-4331084, http://linkedlifedata.com/resource/pubmed/commentcorrection/4350343-4337099, http://linkedlifedata.com/resource/pubmed/commentcorrection/4350343-4555406, http://linkedlifedata.com/resource/pubmed/commentcorrection/4350343-4894690, http://linkedlifedata.com/resource/pubmed/commentcorrection/4350343-4919547, http://linkedlifedata.com/resource/pubmed/commentcorrection/4350343-4924969, http://linkedlifedata.com/resource/pubmed/commentcorrection/4350343-4939624, http://linkedlifedata.com/resource/pubmed/commentcorrection/4350343-5001789, http://linkedlifedata.com/resource/pubmed/commentcorrection/4350343-5340680
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
May
pubmed:issn
0021-9193
pubmed:author
pubmed:issnType
Print
pubmed:volume
114
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
577-91
pubmed:dateRevised
2009-11-18
pubmed:meshHeading
pubmed:year
1973
pubmed:articleTitle
Stimulation by cyclic adenosine monophosphate of plasmid deoxyribonucleic acid replication and catabolite repression of the plasmid deoxyribonucleic acid-protein relaxation complex.
pubmed:publicationType
Journal Article