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Predicate | Object |
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rdf:type | |
lifeskim:mentions | |
pubmed:issue |
3
|
pubmed:dateCreated |
1980-4-23
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pubmed:abstractText |
The cellular localisation of benzodiazepine receptors was studied. Kainic acid induced neuronal lesions (2 x 0.25-2 x 2 micrograms; 2-26 days in rat cerebellum decreased specific binding of [3H]flunitrazepam down to 35% of controls. Specific binding of [3H]flunitrazepam was also decreased (to 80% of controls) in the cerebllum of mutant nervous mouse (nr/nr) where Purkinje cells are degenerated but in the mutant weaver mouse where granule cells are degenerated. These results show that benzodiazepine receptors are located mainly on neurons; both on Purkinje cells and other neurons, but not to a great extent on granule cells.
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pubmed:language |
eng
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pubmed:journal | |
pubmed:citationSubset |
IM
|
pubmed:chemical | |
pubmed:status |
MEDLINE
|
pubmed:month |
Aug
|
pubmed:issn |
0304-3940
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pubmed:author | |
pubmed:issnType |
Print
|
pubmed:volume |
13
|
pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
|
pubmed:pagination |
219-24
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pubmed:dateRevised |
2006-11-15
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pubmed:meshHeading |
pubmed-meshheading:43490-Animals,
pubmed-meshheading:43490-Anti-Anxiety Agents,
pubmed-meshheading:43490-Cerebellum,
pubmed-meshheading:43490-Flunitrazepam,
pubmed-meshheading:43490-Kainic Acid,
pubmed-meshheading:43490-Male,
pubmed-meshheading:43490-Mice,
pubmed-meshheading:43490-Mice, Neurologic Mutants,
pubmed-meshheading:43490-Neuroglia,
pubmed-meshheading:43490-Neurons,
pubmed-meshheading:43490-Rats,
pubmed-meshheading:43490-Receptors, Drug
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pubmed:year |
1979
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pubmed:articleTitle |
Neuronal localisation of benzodiazepine receptors in cerebellum.
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pubmed:publicationType |
Journal Article,
Comparative Study
|