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PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
3
pubmed:dateCreated
1973-1-30
pubmed:abstractText
The (51)Cr-release test was used to detect cytotoxic antibodies in adult rabbits bearing tumors induced by Shope fibroma virus. The following are the recommended experimental conditions: the infection of RK-13 cells with a multiplicity of 1 to 2 infectious units per cell for 48 hr, (51)Cr labeling of infected cells during the last 12 hr of incubation, sensitization of suspended labeled infected cells for 1 hr with immune serum, and quantitation of cell damage by the amount of (51)Cr released after 6 hr of incubation in the presence of complement. The immune sera reacted only with fibroma virus-infected cells but not with cells infected with vaccinia virus or herpesvirus type 1. Similarly, sera prepared against vaccinia virus and herpesvirus type 1 were not cytotoxic to fibroma virus-infected cells, although they were cytotoxic to cells infected with homologous viruses. The total antibody activity in sera of rabbits infected with Shope fibroma virus was detected first on day 7, gradually rose to its peak by day 23, and persisted at that level for at least 50 days. The 19S antibody was detected on day 7, reached peak titers by day 13, and disappeared by day 17. The 7S antibody was barely detectable on day 7, reached maximum titers on day 13, and remained high for at least 50 days. The tumors appeared on the 3rd day after virus inoculation, reached maximum size on day 13, and regressed completely by day 23.
pubmed:commentsCorrections
http://linkedlifedata.com/resource/pubmed/commentcorrection/4344218-13707034, http://linkedlifedata.com/resource/pubmed/commentcorrection/4344218-13945577, http://linkedlifedata.com/resource/pubmed/commentcorrection/4344218-14016859, http://linkedlifedata.com/resource/pubmed/commentcorrection/4344218-14106351, http://linkedlifedata.com/resource/pubmed/commentcorrection/4344218-14212418, http://linkedlifedata.com/resource/pubmed/commentcorrection/4344218-14237205, http://linkedlifedata.com/resource/pubmed/commentcorrection/4344218-14285093, http://linkedlifedata.com/resource/pubmed/commentcorrection/4344218-14493062, http://linkedlifedata.com/resource/pubmed/commentcorrection/4344218-4305647, http://linkedlifedata.com/resource/pubmed/commentcorrection/4344218-4310621, http://linkedlifedata.com/resource/pubmed/commentcorrection/4344218-4311886, http://linkedlifedata.com/resource/pubmed/commentcorrection/4344218-4321290, http://linkedlifedata.com/resource/pubmed/commentcorrection/4344218-4904883, http://linkedlifedata.com/resource/pubmed/commentcorrection/4344218-4927135, http://linkedlifedata.com/resource/pubmed/commentcorrection/4344218-5115906, http://linkedlifedata.com/resource/pubmed/commentcorrection/4344218-5330233, http://linkedlifedata.com/resource/pubmed/commentcorrection/4344218-5818824
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Mar
pubmed:issn
0019-9567
pubmed:author
pubmed:issnType
Print
pubmed:volume
5
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
352-8
pubmed:dateRevised
2009-11-18
pubmed:meshHeading
pubmed-meshheading:4344218-Animals, pubmed-meshheading:4344218-Antibodies, Neoplasm, pubmed-meshheading:4344218-Antibodies, Viral, pubmed-meshheading:4344218-Antibody Specificity, pubmed-meshheading:4344218-Cell Line, pubmed-meshheading:4344218-Chromatography, pubmed-meshheading:4344218-Chromium Isotopes, pubmed-meshheading:4344218-Cytotoxicity Tests, Immunologic, pubmed-meshheading:4344218-Immunity, pubmed-meshheading:4344218-Immunoglobulins, pubmed-meshheading:4344218-Kidney, pubmed-meshheading:4344218-Kinetics, pubmed-meshheading:4344218-Oncogenic Viruses, pubmed-meshheading:4344218-Poxviridae, pubmed-meshheading:4344218-Rabbits, pubmed-meshheading:4344218-Simplexvirus, pubmed-meshheading:4344218-Time Factors, pubmed-meshheading:4344218-Tumor Virus Infections, pubmed-meshheading:4344218-Vaccinia virus
pubmed:year
1972
pubmed:articleTitle
Demonstration of cytotoxic antibodies in rabbits bearing tumors induced by Shope fibroma virus.
pubmed:publicationType
Journal Article