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rdf:type |
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lifeskim:mentions |
umls-concept:C0007623,
umls-concept:C0030958,
umls-concept:C0035820,
umls-concept:C0085493,
umls-concept:C0185023,
umls-concept:C0237497,
umls-concept:C0443286,
umls-concept:C0597605,
umls-concept:C1314972,
umls-concept:C1883254,
umls-concept:C1947904,
umls-concept:C1999228,
umls-concept:C2825781
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pubmed:issue |
11
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pubmed:dateCreated |
1973-1-29
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pubmed:abstractText |
Cell-wall preparations of Micrococcus luteus (lysodeikticus) catalyze in vitro peptidoglycan synthesis from UDP N-acetyl-D-glucosamine, UDP N-acetylmuramic acid-pentapeptide, and glycine. Newly synthesized peptidoglycan is partially cross-linked by a transpeptidation reaction with concomitant release of C-terminal D-alanine. Penicillin not only strongly inhibits release of D-alanine (98% at 1 mug/ml), but also markedly inhibits incorporation of acetylglucosamine and N-acetylmuramic acid-pentapeptide into the preformed cell-wall peptidoglycan. The simplest explanation for the results is that incorporation of newly synthesized strands of peptidoglycan and their attachment to "older" cell-wall peptidoglycan proceeds mainly by transpeptidation and that transglycosylation is responsible only for part of the elongation of the pre-existing peptidoglycan. Another possibility is that incorporation occurs by transglycosylation, but it cannot continue without concurrent formation of peptide cross-bridges.
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/4343965-14106674,
http://linkedlifedata.com/resource/pubmed/commentcorrection/4343965-14285229,
http://linkedlifedata.com/resource/pubmed/commentcorrection/4343965-14324547,
http://linkedlifedata.com/resource/pubmed/commentcorrection/4343965-14420567,
http://linkedlifedata.com/resource/pubmed/commentcorrection/4343965-4259358,
http://linkedlifedata.com/resource/pubmed/commentcorrection/4343965-4919965,
http://linkedlifedata.com/resource/pubmed/commentcorrection/4343965-4926386,
http://linkedlifedata.com/resource/pubmed/commentcorrection/4343965-4959942,
http://linkedlifedata.com/resource/pubmed/commentcorrection/4343965-4960294,
http://linkedlifedata.com/resource/pubmed/commentcorrection/4343965-5216369,
http://linkedlifedata.com/resource/pubmed/commentcorrection/4343965-5563871,
http://linkedlifedata.com/resource/pubmed/commentcorrection/4343965-5677833,
http://linkedlifedata.com/resource/pubmed/commentcorrection/4343965-5961853,
http://linkedlifedata.com/resource/pubmed/commentcorrection/4343965-6027794,
http://linkedlifedata.com/resource/pubmed/commentcorrection/4343965-6064598
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Amino Acids,
http://linkedlifedata.com/resource/pubmed/chemical/Carbon Isotopes,
http://linkedlifedata.com/resource/pubmed/chemical/Cephaloridine,
http://linkedlifedata.com/resource/pubmed/chemical/Glucosamine,
http://linkedlifedata.com/resource/pubmed/chemical/Glycine,
http://linkedlifedata.com/resource/pubmed/chemical/Methicillin,
http://linkedlifedata.com/resource/pubmed/chemical/Muramic Acids,
http://linkedlifedata.com/resource/pubmed/chemical/Oligopeptides,
http://linkedlifedata.com/resource/pubmed/chemical/Penicillanic Acid,
http://linkedlifedata.com/resource/pubmed/chemical/Penicillin G,
http://linkedlifedata.com/resource/pubmed/chemical/Penicillins,
http://linkedlifedata.com/resource/pubmed/chemical/Peptides,
http://linkedlifedata.com/resource/pubmed/chemical/Peptidoglycan,
http://linkedlifedata.com/resource/pubmed/chemical/Protein Precursors,
http://linkedlifedata.com/resource/pubmed/chemical/Uridine Diphosphate Sugars
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pubmed:status |
MEDLINE
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pubmed:month |
Nov
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pubmed:issn |
0027-8424
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
69
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
3355-9
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pubmed:dateRevised |
2009-11-18
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pubmed:meshHeading |
pubmed-meshheading:4343965-Amino Acids,
pubmed-meshheading:4343965-Carbon Isotopes,
pubmed-meshheading:4343965-Cell Wall,
pubmed-meshheading:4343965-Cephaloridine,
pubmed-meshheading:4343965-Glucosamine,
pubmed-meshheading:4343965-Glycine,
pubmed-meshheading:4343965-Methicillin,
pubmed-meshheading:4343965-Micrococcus,
pubmed-meshheading:4343965-Models, Biological,
pubmed-meshheading:4343965-Muramic Acids,
pubmed-meshheading:4343965-Oligopeptides,
pubmed-meshheading:4343965-Penicillanic Acid,
pubmed-meshheading:4343965-Penicillin G,
pubmed-meshheading:4343965-Penicillins,
pubmed-meshheading:4343965-Peptides,
pubmed-meshheading:4343965-Peptidoglycan,
pubmed-meshheading:4343965-Protein Precursors,
pubmed-meshheading:4343965-Uridine Diphosphate Sugars
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pubmed:year |
1972
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pubmed:articleTitle |
Role of the penicillin-sensitive transpeptidation reaction in attachment of newly synthesized peptidoglycan to cell walls of Micrococcus luteus.
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pubmed:publicationType |
Journal Article
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