Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
5
pubmed:dateCreated
1972-10-27
pubmed:abstractText
The physiological basis for the polyuria and polydipsia occurring in some manic-depressive patients treated with lithium salts was studied in vivo and in vitro. Three lithium-treated polyuric patients, in whom other causes of a concentrating defect were excluded, had abnormal urinary concentrating abilities after a standard water depreviation test. Two of these patients failed to respond to exogenous vasopressin (ADH) and one had a subnormal response. The abilities of these patients to excrete solute-free water (C(H2O)) was comparable to normal subjects during steady-state water diuresis, suggesting no gross abnormalities in sodium transport. However, each of these patients demonstrated abnormally low capacities to reabsorb solute-free water (T(C) (H2O)) under hydropenic conditions after administration of hypertonic saline and vasopressin. These in vivo findings demonstrate at least a nephrogenic basis for the diabetes insipidus syndrome manifested by these three patients. The defect in water transport was further characterized in toad urinary bladders in vitro. Short-circuit current (I) and water flow (W) were studied under basal, ADH-stimulated, and cyclic adenosine 3',5'-monophosphate (c-AMP)-stimulated conditions. Increasing mucosal [Li(+)] progressively inhibited basal I, and both I and W induced by ADH. Significant inhibition of basal and ADH-induced I was observed at mucosal [Li(+)] < 1.1 mEq/liter, and of ADH-induced W at mucosal [Li(+)] = 11 mEq/liter. On the other hand, at these lithium concentrations, neither c-AMP-stimulated W nor I was inhibited. Increasing serosal [Li(+)] produced significant inhibition of basal I only at [Li(+)] at least 50-fold greater than at the mucosal (urinary) surface. These in vitro studies confirm that mucosal lithium inhibits the action of ADH, but not c-AMP. Hence, lithium appears to be a significant inhibitor of ADH-stimulated water flow, probably acts from the urinary surface, and appears to exert its effect at a site biochemically proximal to c-AMP action.
pubmed:commentsCorrections
http://linkedlifedata.com/resource/pubmed/commentcorrection/4341501-13587824, http://linkedlifedata.com/resource/pubmed/commentcorrection/4341501-13894805, http://linkedlifedata.com/resource/pubmed/commentcorrection/4341501-14162529, http://linkedlifedata.com/resource/pubmed/commentcorrection/4341501-14212403, http://linkedlifedata.com/resource/pubmed/commentcorrection/4341501-14868510, http://linkedlifedata.com/resource/pubmed/commentcorrection/4341501-4191451, http://linkedlifedata.com/resource/pubmed/commentcorrection/4341501-4245215, http://linkedlifedata.com/resource/pubmed/commentcorrection/4341501-4307204, http://linkedlifedata.com/resource/pubmed/commentcorrection/4341501-4320177, http://linkedlifedata.com/resource/pubmed/commentcorrection/4341501-5337376, http://linkedlifedata.com/resource/pubmed/commentcorrection/4341501-5337377, http://linkedlifedata.com/resource/pubmed/commentcorrection/4341501-5337378, http://linkedlifedata.com/resource/pubmed/commentcorrection/4341501-5442790, http://linkedlifedata.com/resource/pubmed/commentcorrection/4341501-5480858, http://linkedlifedata.com/resource/pubmed/commentcorrection/4341501-5538641, http://linkedlifedata.com/resource/pubmed/commentcorrection/4341501-5574669, http://linkedlifedata.com/resource/pubmed/commentcorrection/4341501-5824332, http://linkedlifedata.com/resource/pubmed/commentcorrection/4341501-5911047
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
AIM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
May
pubmed:issn
0021-9738
pubmed:author
pubmed:issnType
Print
pubmed:volume
51
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
1081-91
pubmed:dateRevised
2009-11-18
pubmed:meshHeading
pubmed-meshheading:4341501-Adult, pubmed-meshheading:4341501-Animals, pubmed-meshheading:4341501-Anura, pubmed-meshheading:4341501-Biological Transport, Active, pubmed-meshheading:4341501-Bipolar Disorder, pubmed-meshheading:4341501-Cyclic AMP, pubmed-meshheading:4341501-Diabetes Insipidus, pubmed-meshheading:4341501-Drinking Behavior, pubmed-meshheading:4341501-Humans, pubmed-meshheading:4341501-Kidney, pubmed-meshheading:4341501-Kidney Concentrating Ability, pubmed-meshheading:4341501-Lithium, pubmed-meshheading:4341501-Male, pubmed-meshheading:4341501-Membrane Potentials, pubmed-meshheading:4341501-Middle Aged, pubmed-meshheading:4341501-Osmolar Concentration, pubmed-meshheading:4341501-Polyuria, pubmed-meshheading:4341501-Sodium, pubmed-meshheading:4341501-Urinary Bladder, pubmed-meshheading:4341501-Vasopressins, pubmed-meshheading:4341501-Water-Electrolyte Balance
pubmed:year
1972
pubmed:articleTitle
Lithium-induced nephrogenic diabetes insipidus: in vivo and in vitro studies.
pubmed:publicationType
Journal Article, In Vitro