Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
2
pubmed:dateCreated
1972-7-3
pubmed:abstractText
The systemic fungicide carboxin (5,6-dihydro-2-methyl-1,4-oxathiin-3-carboxanilide) at 100 mum inhibited succinate cytochrome c reductase in mitochondria from Ustilago maydis and Saccharomyces cerevisiae. It did not have any effect on reduced nicotinamide adenine dinucleotide (NADH) cytochrome c reductase. Succinate coenzyme Q reductase was also inhibited, but NADH coenzyme Q reductase was not. When dichlorophenolindophenol (DCIP) was used as the terminal acceptor of electrons from the oxidation of succinate, carboxin was very effective in inhibiting succinate-DCIP reductase. Carboxin was inhibitory to succinic dehydrogenase assayed with phenazine methosulfate plus DCIP when intact mitochondria were used as the enzyme source but not when solubilized enzyme was used. The main site of action of carboxin, therefore, appears to lie between succinate and coenzyme Q. The dioxide analogue of carboxin was also effective in inhibiting succinate-cytochrome c reductase, succinate-coenzyme Q reductase, or succinate-DCIP reductase, whereas the monoxide analogue was less effective in inhibiting these enzymes.
pubmed:commentsCorrections
http://linkedlifedata.com/resource/pubmed/commentcorrection/4336692-13382877, http://linkedlifedata.com/resource/pubmed/commentcorrection/4336692-13445213, http://linkedlifedata.com/resource/pubmed/commentcorrection/4336692-13739312, http://linkedlifedata.com/resource/pubmed/commentcorrection/4336692-13862582, http://linkedlifedata.com/resource/pubmed/commentcorrection/4336692-14907713, http://linkedlifedata.com/resource/pubmed/commentcorrection/4336692-16656487, http://linkedlifedata.com/resource/pubmed/commentcorrection/4336692-17779512, http://linkedlifedata.com/resource/pubmed/commentcorrection/4336692-17780003, http://linkedlifedata.com/resource/pubmed/commentcorrection/4336692-4310080, http://linkedlifedata.com/resource/pubmed/commentcorrection/4336692-4313602, http://linkedlifedata.com/resource/pubmed/commentcorrection/4336692-4323963, http://linkedlifedata.com/resource/pubmed/commentcorrection/4336692-5160406, http://linkedlifedata.com/resource/pubmed/commentcorrection/4336692-5441309, http://linkedlifedata.com/resource/pubmed/commentcorrection/4336692-5481090, http://linkedlifedata.com/resource/pubmed/commentcorrection/4336692-5481394, http://linkedlifedata.com/resource/pubmed/commentcorrection/4336692-5529696, http://linkedlifedata.com/resource/pubmed/commentcorrection/4336692-5531164, http://linkedlifedata.com/resource/pubmed/commentcorrection/4336692-5689164, http://linkedlifedata.com/resource/pubmed/commentcorrection/4336692-6075007
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
May
pubmed:issn
0021-9193
pubmed:author
pubmed:issnType
Print
pubmed:volume
110
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
628-32
pubmed:dateRevised
2010-9-13
pubmed:meshHeading
pubmed:year
1972
pubmed:articleTitle
Mode of action of oxathiin systemic fungicides. V. Effect on electron transport system of Ustilago maydis and Saccharomyces cerevisiae.
pubmed:publicationType
Journal Article