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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
9
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pubmed:dateCreated |
1972-3-9
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pubmed:abstractText |
The size of virus-specific RNA synthesized in cultured mouse kidney cells infected with polyoma virus was estimated by electrophoresis and sedimentation analysis of RNA extracts from whole cells. Newly synthesized "late" polyoma-specific RNA appears as "giant" molecules of heterogeneous size, up to several times larger than a strand of polyoma DNA (1.5 x 10(6) daltons). Treatment with dimethylsulfoxide or urea showed that the large size of these molecules is not due to aggregation. Giant polyoma-specific RNA is strikingly similar in size distribution to "nuclear messenger-like" RNA ("heterogeneous nuclear" RNA) of the host cell. Subsequent to its synthesis, some of the giant polyoma-specific RNA appears to be cleaved to at least three smaller species.
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/4332250-14001211,
http://linkedlifedata.com/resource/pubmed/commentcorrection/4332250-4288987,
http://linkedlifedata.com/resource/pubmed/commentcorrection/4332250-4289760,
http://linkedlifedata.com/resource/pubmed/commentcorrection/4332250-4295314,
http://linkedlifedata.com/resource/pubmed/commentcorrection/4332250-4302639,
http://linkedlifedata.com/resource/pubmed/commentcorrection/4332250-4303488,
http://linkedlifedata.com/resource/pubmed/commentcorrection/4332250-4306661,
http://linkedlifedata.com/resource/pubmed/commentcorrection/4332250-4313194,
http://linkedlifedata.com/resource/pubmed/commentcorrection/4332250-4955314,
http://linkedlifedata.com/resource/pubmed/commentcorrection/4332250-5230317,
http://linkedlifedata.com/resource/pubmed/commentcorrection/4332250-5339944,
http://linkedlifedata.com/resource/pubmed/commentcorrection/4332250-5357212,
http://linkedlifedata.com/resource/pubmed/commentcorrection/4332250-5471476,
http://linkedlifedata.com/resource/pubmed/commentcorrection/4332250-5497892,
http://linkedlifedata.com/resource/pubmed/commentcorrection/4332250-5654613,
http://linkedlifedata.com/resource/pubmed/commentcorrection/4332250-5693297,
http://linkedlifedata.com/resource/pubmed/commentcorrection/4332250-5969070,
http://linkedlifedata.com/resource/pubmed/commentcorrection/4332250-5969071
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Sep
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pubmed:issn |
0027-8424
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
68
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
2231-5
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pubmed:dateRevised |
2009-11-18
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pubmed:meshHeading |
pubmed-meshheading:4332250-Animals,
pubmed-meshheading:4332250-Autoradiography,
pubmed-meshheading:4332250-Carbon Isotopes,
pubmed-meshheading:4332250-Cells, Cultured,
pubmed-meshheading:4332250-Centrifugation, Density Gradient,
pubmed-meshheading:4332250-Electrophoresis, Disc,
pubmed-meshheading:4332250-Genetic Code,
pubmed-meshheading:4332250-Kidney,
pubmed-meshheading:4332250-Mice,
pubmed-meshheading:4332250-Molecular Weight,
pubmed-meshheading:4332250-Nucleic Acid Hybridization,
pubmed-meshheading:4332250-Polyomavirus,
pubmed-meshheading:4332250-RNA,
pubmed-meshheading:4332250-RNA, Viral,
pubmed-meshheading:4332250-Tritium,
pubmed-meshheading:4332250-Uridine
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pubmed:year |
1971
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pubmed:articleTitle |
Transcription of the polyoma virus genome: synthesis and cleavage of giant late polyoma-specific RNA.
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pubmed:publicationType |
Journal Article
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