Linked Life Data

4330960

Source:http://linkedlifedata.com/resource/pubmed/id/4330960

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
1
pubmed:dateCreated
1972-2-11
pubmed:abstractText
1. Concentrations of cyclic AMP (adenosine 3':5'-cyclic monophosphate) and rates of insulin release were measured in islets of Langerhans isolated from rat pancreas and incubated for various times in the presence of glucose, 3-isobutyl-1-methylxanthine, caffeine, theophylline, adrenaline and diazoxide. 2. Caffeine and theophylline produced small but significant increases in both cyclic AMP and release of insulin when they were incubated in the presence of 10mm-glucose. 3. 3-Isobutyl-1-methylxanthine produced a marked increase in the intracellular concentration of cyclic AMP in the presence of 5mm- and 10mm-glucose. However, insulin release was stimulated only in the presence of 10mm-glucose. 4. In response to rising concentrations of extracellular glucose (5-20mm) there was no detectable increase in the intracellular concentration of cyclic AMP even though there was a marked increase in the rate of insulin release. 5. In response to 10mm-glucose insulin release occurred in two phases and 3-isobutyl-1-methylxanthine potentiated the effect of glucose on both phases. The intracellular concentration of cyclic AMP remained constant with glucose and rose within 10min to its maximum value with 3-isobutyl-1-methylxanthine. 6. Adrenaline and diazoxide inhibited insulin release and lowered the intracellular concentration of cyclic AMP when islets were incubated with glucose or 3-isobutyl-1-methylxanthine. 7. It is suggested that glucose does not stimulate insulin release by increasing the concentration of cyclic AMP in islet cells. However, the concentration of cyclic AMP in islet cells may modulate the effect of glucose on the release process.
pubmed:commentsCorrections
http://linkedlifedata.com/resource/pubmed/commentcorrection/4330960-13952078, http://linkedlifedata.com/resource/pubmed/commentcorrection/4330960-14300765, http://linkedlifedata.com/resource/pubmed/commentcorrection/4330960-14907713, http://linkedlifedata.com/resource/pubmed/commentcorrection/4330960-4184216, http://linkedlifedata.com/resource/pubmed/commentcorrection/4330960-4244886, http://linkedlifedata.com/resource/pubmed/commentcorrection/4330960-4294054, http://linkedlifedata.com/resource/pubmed/commentcorrection/4330960-4297287, http://linkedlifedata.com/resource/pubmed/commentcorrection/4330960-4297939, http://linkedlifedata.com/resource/pubmed/commentcorrection/4330960-4309599, http://linkedlifedata.com/resource/pubmed/commentcorrection/4330960-4309607, http://linkedlifedata.com/resource/pubmed/commentcorrection/4330960-4310313, http://linkedlifedata.com/resource/pubmed/commentcorrection/4330960-4311197, http://linkedlifedata.com/resource/pubmed/commentcorrection/4330960-4315101, http://linkedlifedata.com/resource/pubmed/commentcorrection/4330960-4378937, http://linkedlifedata.com/resource/pubmed/commentcorrection/4330960-4877098, http://linkedlifedata.com/resource/pubmed/commentcorrection/4330960-4879533, http://linkedlifedata.com/resource/pubmed/commentcorrection/4330960-5339448
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Mar
pubmed:issn
0264-6021
pubmed:author
pubmed:issnType
Print
pubmed:volume
122
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
115-20
pubmed:dateRevised
2011-11-17
pubmed:meshHeading
pubmed:year
1971
pubmed:articleTitle
The role of adenosine 3':5'-cyclic monophosphate in the regulation of insulin release by isolated rat islets of Langerhans.
pubmed:publicationType
Journal Article, In Vitro