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A protein kinase that is dependent on cAMP was found to be present in significant amounts in rat and bovine pineal glands. This enzyme system was isolated from bovine pineal glands and shown to consist of two proteins, a kinase and a cAMP-binding protein. The kinase primarily phosphorylates histones and may function in the control of the diurnal variation of the enzymes in the melatonin biosynthetic pathway.
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