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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
5
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pubmed:dateCreated |
1969-11-4
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pubmed:abstractText |
1. The effect of pH on the co-operative activation of the NAD-specific isocitrate dehydrogenase from pea mitochondria by isocitrate is shown. 2. The interlinked effects of pH on the affinity of the NAD-specific isocitrate dehydrogenase for isocitrate and the dependence of the pH optimum on the substrate concentration are presented. 3. A consideration of the conditions of pH and substrate concentration under which citrate activates the NAD-specific isocitrate dehydrogenase demonstrates similarities between the binding of isocitrate and citrate. 4. A comparison of the effects of citrate and pH on the gross structure of the enzyme is investigated by density-gradient centrifugation. 5. The kinetic interpretations of these results are briefly considered. 6. The metabolic significance of these studies is discussed.
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/4309595-13058835,
http://linkedlifedata.com/resource/pubmed/commentcorrection/4309595-13093634,
http://linkedlifedata.com/resource/pubmed/commentcorrection/4309595-13767412,
http://linkedlifedata.com/resource/pubmed/commentcorrection/4309595-14063317,
http://linkedlifedata.com/resource/pubmed/commentcorrection/4309595-14068494,
http://linkedlifedata.com/resource/pubmed/commentcorrection/4309595-14087354,
http://linkedlifedata.com/resource/pubmed/commentcorrection/4309595-14189899,
http://linkedlifedata.com/resource/pubmed/commentcorrection/4309595-14262437,
http://linkedlifedata.com/resource/pubmed/commentcorrection/4309595-14304886,
http://linkedlifedata.com/resource/pubmed/commentcorrection/4309595-16742267,
http://linkedlifedata.com/resource/pubmed/commentcorrection/4309595-4286144,
http://linkedlifedata.com/resource/pubmed/commentcorrection/4309595-4296325,
http://linkedlifedata.com/resource/pubmed/commentcorrection/4309595-5938952,
http://linkedlifedata.com/resource/pubmed/commentcorrection/4309595-5942950,
http://linkedlifedata.com/resource/pubmed/commentcorrection/4309595-5961071,
http://linkedlifedata.com/resource/pubmed/commentcorrection/4309595-6023568,
http://linkedlifedata.com/resource/pubmed/commentcorrection/4309595-6040889
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Aug
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pubmed:issn |
0264-6021
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
113
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
813-20
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pubmed:dateRevised |
2009-11-18
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pubmed:meshHeading |
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pubmed:year |
1969
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pubmed:articleTitle |
The effects of pH and citrate on the activity of nicotinamideA-denine dinucleotide-specific isocitrate dehydrogenase from pea mitochondria.
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pubmed:publicationType |
Journal Article
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