Linked Life Data

430370

Source:http://linkedlifedata.com/resource/pubmed/id/430370

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
1
pubmed:dateCreated
1979-6-26
pubmed:abstractText
Amphetamine and phenylethylamine stimulate dopamine synthesis in rat brain striatal synaptosomes via a calcium- and tyrosine-dependent mechanism. The similarity of this stimulation to that produced by depolarizing concentrations of veratridine, along with the non-additivity of maximally stimulating concentrations of amphetamine and veratridine, suggests that these treatments may all share a common locus of action. Differences in exact modes of action can be seen, however, in the blockade only of the stimulation of veratridine by tetrodotoxin, and by the lack of effect of amphetamine or phenylethylamine on tyrosine uptake. At high concentrations, amphetamine and phenylethylamine lose their ability to stimulate dopamine synthesis and produce an antagonism of veratridine-induced synthesis stimulation.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Apr
pubmed:issn
0022-3565
pubmed:author
pubmed:issnType
Print
pubmed:volume
209
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
104-10
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed:year
1979
pubmed:articleTitle
Amphetamine- and phenylethylamine-induced alterations in dopamine synthesis regulation in rat brain striatal synaptosomes.
pubmed:publicationType
Journal Article, In Vitro, Research Support, U.S. Gov't, P.H.S.