Linked Life Data

4300135

Source:http://linkedlifedata.com/resource/pubmed/id/4300135

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
1
pubmed:dateCreated
1968-11-1
pubmed:abstractText
1. The effects of anticholinesterases (anti-ChEs) (physostigmine, prostigmine and TEPP) on the afterdischarges and the extracellular and intracellular slow potentials of bullfrog sympathetic ganglia were studied.2. The anti-ChEs augmented the early afterdischarge, the late negative potential and the slow excitatory postsynaptic potential. This indicated that the nature of the early afterdischarge was cholinergic (muscarinic) and that the late negative potential or the slow excitatory postsynaptic potential generated the early afterdischarge.3. Since the anti-ChEs increased the positive potential, the depression of the early afterdischarge observed in the presence of an antiChE was explained to be caused by the increased inhibitory effect of the enhanced positive potential.4. Prostigmine and tetraethyl pyrophosphate did not show any appreciable effects on the late afterdischarge, the late late negative potential nor the late slow excitatory postsynaptic potential. This indicated that the nature of the late afterdischarge was non-cholinergic and that the late late negative potential or the late slow excitatory postsynaptic potential generated the late afterdischarge.5. Physostigmine reversibly depressed the late afterdischarge, the late late negative potential and the late slow excitatory postsynaptic potential. The depressant action of physostigmine was not due to its anti-ChE action.
pubmed:commentsCorrections
http://linkedlifedata.com/resource/pubmed/commentcorrection/4300135-13320349, http://linkedlifedata.com/resource/pubmed/commentcorrection/4300135-13725578, http://linkedlifedata.com/resource/pubmed/commentcorrection/4300135-13926636, http://linkedlifedata.com/resource/pubmed/commentcorrection/4300135-13984670, http://linkedlifedata.com/resource/pubmed/commentcorrection/4300135-13984671, http://linkedlifedata.com/resource/pubmed/commentcorrection/4300135-14955809, http://linkedlifedata.com/resource/pubmed/commentcorrection/4300135-15436542, http://linkedlifedata.com/resource/pubmed/commentcorrection/4300135-4295893, http://linkedlifedata.com/resource/pubmed/commentcorrection/4300135-5857909, http://linkedlifedata.com/resource/pubmed/commentcorrection/4300135-6037590, http://linkedlifedata.com/resource/pubmed/commentcorrection/4300135-6052680, http://linkedlifedata.com/resource/pubmed/commentcorrection/4300135-6060261
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Sep
pubmed:issn
0007-1188
pubmed:author
pubmed:issnType
Print
pubmed:volume
34
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
177-88
pubmed:dateRevised
2009-11-18
pubmed:meshHeading
pubmed:year
1968
pubmed:articleTitle
Effects of physostigmine on the afterdischarge and slow postsynaptic potentials of bullfrog sympathetic ganglia.
pubmed:publicationType
Journal Article, In Vitro