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Predicate | Object |
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rdf:type | |
lifeskim:mentions | |
pubmed:issue |
3
|
pubmed:dateCreated |
1979-6-29
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pubmed:abstractText |
The effect of oral administration of sulpiride on PRL secretion and initiation of puerperal lactation was studied in 130 randomly selected primiparous nursing mothers. Sixty-six women were given 50 mg sulpiride orally twice a day during the first 7 days of the puerperium (sulpiride group). Sixty-four women were given a placebo in the same way (control group). The mean (+/-SE) total milk yield during the first 5 postpartum days in the sulpiride group (1211.7 +/- 65.0 ml) was significantly greater than that in the control group (916.0 +/- 66.0 ml). Every other day determinations of serum PRL levels revealed significantly higher concentrations in the sulpiride group than in the control group. A single oral dose of 50 mg sulpiride raised serum PRL levels for 12 h, with a peak level at 2 h after dosing in 7 women on the second postpartum day. These data suggest that sulpiride given orally promotes the initiation of lactation in puerperal women by stimulating PRL secretion.
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pubmed:language |
eng
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pubmed:journal | |
pubmed:citationSubset |
AIM
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pubmed:chemical | |
pubmed:status |
MEDLINE
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pubmed:month |
Mar
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pubmed:issn |
0021-972X
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pubmed:author | |
pubmed:issnType |
Print
|
pubmed:volume |
48
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pubmed:owner |
NLM
|
pubmed:authorsComplete |
Y
|
pubmed:pagination |
478-82
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pubmed:dateRevised |
2004-11-17
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pubmed:meshHeading |
pubmed-meshheading:429499-Adult,
pubmed-meshheading:429499-Birth Weight,
pubmed-meshheading:429499-Female,
pubmed-meshheading:429499-Humans,
pubmed-meshheading:429499-Infant, Newborn,
pubmed-meshheading:429499-Lactation,
pubmed-meshheading:429499-Male,
pubmed-meshheading:429499-Milk, Human,
pubmed-meshheading:429499-Pregnancy,
pubmed-meshheading:429499-Prolactin,
pubmed-meshheading:429499-Sulpiride
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pubmed:year |
1979
|
pubmed:articleTitle |
Augmentation of puerperal lactation by oral administration of sulpiride.
|
pubmed:publicationType |
Journal Article,
Clinical Trial,
Controlled Clinical Trial
|