Linked Life Data

4294053

Source:http://linkedlifedata.com/resource/pubmed/id/4294053

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
11
pubmed:dateCreated
1968-1-22
pubmed:abstractText
We have investigated the possibility that alterations in the duration of the systolic preejection period can be used to estimate adrenergic influences on the human left ventricle. The preejection period was determined from high speed, simultaneous recordings of the phonocardiogram, carotid pulse tracing, and electrocardiogram. The preejection period was shortened by isoproterenol, epinephrine, and moderate doses of norepinephrine-all of which activate beta adrenergic receptors-and by cedilanid-D. It was unaltered by changes in heart rate induced by atropine and right atrial electrical pacing. Beta adrenergic receptor blockade by propranolol abolished the shortening effects of the three catecholamines but did not inhibit that due to cedilanid-D. Vasoconstriction, both alpha adrenergic (epinephrine and norepinephrine after propranolol) and nonadrenergic (angiotensin), prolonged the preejection period. Most of the shortening of the preejection period by beta adrenergic receptor activating agents and cedilanid-D and all of the prolongation accompanying pharmacologic vasoconstriction occurred after the onset of the first heart sound, thereby excluding changes in electrical-mechanical delay as a major factor in the observed preejection period responses. Shortening of the preejection period by beta adrenergic activity induced with isoproterenol was dose-related. Increasing doses of propranolol produced parallel shifts to the right in the isoproterenol dose-response curve. In 37 normal resting subjects intravenous propranolol (10 mg) prolonged the preejection period an average of 10 (SE +/- 1) msec. In six patients with psychogenic sinus tachycardia and a patient with a pheochromocytoma the presence of excessive beta adrenergic influences on the left ventricle was demonstrated by the finding of an initially short preejection period which responded with an abnormally great prolongation to beta adrenergic receptor blockade.
pubmed:commentsCorrections
http://linkedlifedata.com/resource/pubmed/commentcorrection/4294053-13588535, http://linkedlifedata.com/resource/pubmed/commentcorrection/4294053-13597000, http://linkedlifedata.com/resource/pubmed/commentcorrection/4294053-13740337, http://linkedlifedata.com/resource/pubmed/commentcorrection/4294053-13998538, http://linkedlifedata.com/resource/pubmed/commentcorrection/4294053-14132613, http://linkedlifedata.com/resource/pubmed/commentcorrection/4294053-14153945, http://linkedlifedata.com/resource/pubmed/commentcorrection/4294053-14226170, http://linkedlifedata.com/resource/pubmed/commentcorrection/4294053-14314184, http://linkedlifedata.com/resource/pubmed/commentcorrection/4294053-14322032, http://linkedlifedata.com/resource/pubmed/commentcorrection/4294053-16992821, http://linkedlifedata.com/resource/pubmed/commentcorrection/4294053-5912680, http://linkedlifedata.com/resource/pubmed/commentcorrection/4294053-5913013, http://linkedlifedata.com/resource/pubmed/commentcorrection/4294053-5914847, http://linkedlifedata.com/resource/pubmed/commentcorrection/4294053-5929654
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
AIM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Nov
pubmed:issn
0021-9738
pubmed:author
pubmed:issnType
Print
pubmed:volume
46
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
1704-14
pubmed:dateRevised
2009-11-18
pubmed:meshHeading
pubmed:year
1967
pubmed:articleTitle
Effects of adrenergic receptor activation and blockade on the systolic preejection period, heart rate, and arterial pressure in man.
pubmed:publicationType
Journal Article