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Predicate | Object |
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rdf:type | |
lifeskim:mentions | |
pubmed:issue |
5
|
pubmed:dateCreated |
1980-3-17
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pubmed:abstractText |
Metabolic turnover of NADP+ labeled with 14C in the ribose moiety of their molecules was determined in the ascites cells of sarcoma Sa 180 and in the rat liver tissue. The half-lives of NAD+ and NADP+ in the Sa 180 sarcoma cells were 60 min (NAD+) and 90 min (NADP+) and 120 min (NADP+). Experiments were done on animals to study the time-dependent effect of ionizing radiation on the values of pooled NAD+ and NADP+ after 0.129 C/kg (500 R) and 0.387 C/kg (1500 R) whole-body irradiation, and the metabolic turnover of these nucleotides 5 h after whole-body irradiation with 0.387 C/kg (1500 R). Exposure to 0.129 C/kg (500 R) whole-body irradiation induced no apparent changes compared to the controls. Within 5 h of irradiation the whole-body dose of 0.387 C/kg (1500 R) produced changes in rat liver cells characterized by a reduction of the nucleotide biological half-lives (NAD+ from 80 to 60 min and NADP+ from 120 to 70 min). No such changes in the pyridine nucleotide turnover were detected in Sa 180 ascites sarcoma cells.
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pubmed:language |
eng
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pubmed:journal | |
pubmed:citationSubset |
IM
|
pubmed:chemical | |
pubmed:status |
MEDLINE
|
pubmed:issn |
0028-2685
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pubmed:author | |
pubmed:issnType |
Print
|
pubmed:volume |
26
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pubmed:owner |
NLM
|
pubmed:authorsComplete |
Y
|
pubmed:pagination |
565-75
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pubmed:dateRevised |
2006-11-15
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pubmed:meshHeading |
pubmed-meshheading:42856-Animals,
pubmed-meshheading:42856-Ascitic Fluid,
pubmed-meshheading:42856-Liver,
pubmed-meshheading:42856-Male,
pubmed-meshheading:42856-Mice,
pubmed-meshheading:42856-NAD,
pubmed-meshheading:42856-NADP,
pubmed-meshheading:42856-Radiation, Ionizing,
pubmed-meshheading:42856-Rats,
pubmed-meshheading:42856-Sarcoma, Experimental
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pubmed:year |
1979
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pubmed:articleTitle |
Metabolic turnover of pyridine nucleotides in ascites cells of sarcoma Sa 180 and in the liver tissue of rats before and after ionizing radiation.
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pubmed:publicationType |
Journal Article,
Comparative Study
|