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rdf:type |
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lifeskim:mentions |
umls-concept:C0017725,
umls-concept:C0017911,
umls-concept:C0018787,
umls-concept:C0021641,
umls-concept:C0034693,
umls-concept:C0150312,
umls-concept:C0205307,
umls-concept:C0333668,
umls-concept:C0597295,
umls-concept:C1280500,
umls-concept:C1549542
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pubmed:issue |
3
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pubmed:dateCreated |
1973-10-14
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pubmed:abstractText |
In the absence of glucose, insulin stimulated the incorporation of (14)C-labelled amino acids into protein by perfused rat hearts that had been previously substantially depleted of endogenous glucose, glucose 6-phosphate and glycogen by substrate-free perfusion. This stimulation was also demonstrated in hearts perfused with buffer containing 2-deoxy-d-glucose, an inhibitor of glucose utilization. It is concluded that insulin exerts an effect on protein synthesis independent of its action on glucose metabolism. Streptozotocin-induced diabetes was found to have no effect either on (14)C-labelled amino acid incorporation by the perfused heart or on the polyribosome profile and amino acid-incorporating activity of polyribosomes prepared from the non-perfused hearts of these insulin-deficient rats, which show marked abnormalities in glucose metabolism. Protein synthesis was not diminished in the perfused hearts from rats treated with anti-insulin antiserum. The significance of these findings is discussed in relation to the reported effects of insulin deficiency on protein synthesis in skeletal muscle.
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/4269308-12999777,
http://linkedlifedata.com/resource/pubmed/commentcorrection/4269308-13405925,
http://linkedlifedata.com/resource/pubmed/commentcorrection/4269308-13596350,
http://linkedlifedata.com/resource/pubmed/commentcorrection/4269308-13610915,
http://linkedlifedata.com/resource/pubmed/commentcorrection/4269308-13649907,
http://linkedlifedata.com/resource/pubmed/commentcorrection/4269308-13699988,
http://linkedlifedata.com/resource/pubmed/commentcorrection/4269308-13766024,
http://linkedlifedata.com/resource/pubmed/commentcorrection/4269308-13772576,
http://linkedlifedata.com/resource/pubmed/commentcorrection/4269308-13884744,
http://linkedlifedata.com/resource/pubmed/commentcorrection/4269308-14008266,
http://linkedlifedata.com/resource/pubmed/commentcorrection/4269308-14251924,
http://linkedlifedata.com/resource/pubmed/commentcorrection/4269308-14285505,
http://linkedlifedata.com/resource/pubmed/commentcorrection/4269308-14346089,
http://linkedlifedata.com/resource/pubmed/commentcorrection/4269308-14351177,
http://linkedlifedata.com/resource/pubmed/commentcorrection/4269308-14907713,
http://linkedlifedata.com/resource/pubmed/commentcorrection/4269308-15404816,
http://linkedlifedata.com/resource/pubmed/commentcorrection/4269308-4291786,
http://linkedlifedata.com/resource/pubmed/commentcorrection/4269308-4302428,
http://linkedlifedata.com/resource/pubmed/commentcorrection/4269308-4953780,
http://linkedlifedata.com/resource/pubmed/commentcorrection/4269308-5135234,
http://linkedlifedata.com/resource/pubmed/commentcorrection/4269308-5353528,
http://linkedlifedata.com/resource/pubmed/commentcorrection/4269308-5503786,
http://linkedlifedata.com/resource/pubmed/commentcorrection/4269308-5540892,
http://linkedlifedata.com/resource/pubmed/commentcorrection/4269308-5698033,
http://linkedlifedata.com/resource/pubmed/commentcorrection/4269308-5721472,
http://linkedlifedata.com/resource/pubmed/commentcorrection/4269308-5863321,
http://linkedlifedata.com/resource/pubmed/commentcorrection/4269308-6015747,
http://linkedlifedata.com/resource/pubmed/commentcorrection/4269308-6028755,
http://linkedlifedata.com/resource/pubmed/commentcorrection/4269308-6049403
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Mar
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pubmed:issn |
0264-6021
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pubmed:author |
|
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pubmed:issnType |
Print
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pubmed:volume |
132
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
593-601
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pubmed:dateRevised |
2011-11-17
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pubmed:meshHeading |
pubmed-meshheading:4269308-Animals,
pubmed-meshheading:4269308-Blood Glucose,
pubmed-meshheading:4269308-Carbon Isotopes,
pubmed-meshheading:4269308-Centrifugation, Density Gradient,
pubmed-meshheading:4269308-Diabetes Mellitus,
pubmed-meshheading:4269308-Glucose,
pubmed-meshheading:4269308-Glucosephosphates,
pubmed-meshheading:4269308-Glycogen,
pubmed-meshheading:4269308-Guinea Pigs,
pubmed-meshheading:4269308-Heart,
pubmed-meshheading:4269308-Immune Sera,
pubmed-meshheading:4269308-Insulin,
pubmed-meshheading:4269308-Insulin Antibodies,
pubmed-meshheading:4269308-Kinetics,
pubmed-meshheading:4269308-Male,
pubmed-meshheading:4269308-Muscle Proteins,
pubmed-meshheading:4269308-Myocardium,
pubmed-meshheading:4269308-Perfusion,
pubmed-meshheading:4269308-Polyribosomes,
pubmed-meshheading:4269308-Rats,
pubmed-meshheading:4269308-Streptozocin
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pubmed:year |
1973
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pubmed:articleTitle |
Protein synthesis by perfused hearts from normal and insulin-deficient rats. Effect of insulin in the presence of glucose and after depletion of glucose, glucose 6-phosphate and glycogen.
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pubmed:publicationType |
Journal Article
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