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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
4162
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pubmed:dateCreated |
1974-12-17
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pubmed:abstractText |
Monomeric ribonuclease A has very low activity toward typically double-stranded RNA's; the dimeric form of ribonuclease A obtained by cross linking the enzyme by dimethyl suberimidate has more than 78 times the activity of the monomer toward polyadenylate . polyuridylate and 440 times the activity of the monomer toward the double-stranded RNA of a virus from Penicillium chrysogenum. The half-life of the dimer in the bloodstream of the rat is 12 times that of the mononmer.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Nov
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pubmed:issn |
0036-8075
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:day |
1
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pubmed:volume |
186
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
444-5
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pubmed:dateRevised |
2008-11-21
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pubmed:meshHeading |
pubmed-meshheading:4213284-Animals,
pubmed-meshheading:4213284-Cattle,
pubmed-meshheading:4213284-Chemical Phenomena,
pubmed-meshheading:4213284-Chemistry,
pubmed-meshheading:4213284-Chromatography, Gel,
pubmed-meshheading:4213284-Electrophoresis,
pubmed-meshheading:4213284-Half-Life,
pubmed-meshheading:4213284-Hydrogen-Ion Concentration,
pubmed-meshheading:4213284-Kinetics,
pubmed-meshheading:4213284-Molecular Weight,
pubmed-meshheading:4213284-Nucleic Acid Conformation,
pubmed-meshheading:4213284-Pancreas,
pubmed-meshheading:4213284-Penicillium chrysogenum,
pubmed-meshheading:4213284-Poly A-U,
pubmed-meshheading:4213284-Polymers,
pubmed-meshheading:4213284-Protein Conformation,
pubmed-meshheading:4213284-RNA, Viral,
pubmed-meshheading:4213284-Ribonucleases,
pubmed-meshheading:4213284-Sodium Dodecyl Sulfate,
pubmed-meshheading:4213284-Structure-Activity Relationship
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pubmed:year |
1974
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pubmed:articleTitle |
Pancreatic ribonuclease: enzymic and physiological properties of a cross-linked dimer.
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pubmed:publicationType |
Journal Article
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