Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
6
pubmed:dateCreated
1974-7-20
pubmed:abstractText
The urine of patients with chronic uremia contains a gel filtration fraction that is natriuretic in the rat. The effects of this fraction on the isolated urinary bladder of the toad were examined in the present studies. When added to the serosal surface of the bladder, a significant and substantial fall in short-circuit current and potential difference was observed. The changes began after a lag period of at least 10 min and continued over a period of 60 min. The decrease in short-circuit current at the end of 1 h averaged 44%. The same fraction from the urine of normal subjects produced no significant change in either short-circuit current or potential difference. When the isolated epithelial cells from the toad bladder were incubated in the presence of the inhibitor, intracellular sodium content increased significantly. There was no change in intracellular water content; hence the intracellular concentration of sodium increased by a mean of 7 meq/liter. The changes in intracellular potassium content and concentration were not satistically significant. When the isolated epithelia were incubated with the uremic factor, there was also a significant decrease in pyruvate utilization in relation to cells from paired hemibladders incubated in the absence of the fraction. The fraction from normal subjects produced no change in either intracellular sodium content or pyruvate oxidation. The results suggest that the inhibitor acts from the serosal surface, inhibits sodium transport across the serosal barrier, and produces a decrease in substrate utilization in association with the change in transepithelial sodium transport.
pubmed:commentsCorrections
http://linkedlifedata.com/resource/pubmed/commentcorrection/4208469-4300150, http://linkedlifedata.com/resource/pubmed/commentcorrection/4208469-4306583, http://linkedlifedata.com/resource/pubmed/commentcorrection/4208469-4623332, http://linkedlifedata.com/resource/pubmed/commentcorrection/4208469-4811199, http://linkedlifedata.com/resource/pubmed/commentcorrection/4208469-4830222, http://linkedlifedata.com/resource/pubmed/commentcorrection/4208469-4939799, http://linkedlifedata.com/resource/pubmed/commentcorrection/4208469-5024044, http://linkedlifedata.com/resource/pubmed/commentcorrection/4208469-5087813, http://linkedlifedata.com/resource/pubmed/commentcorrection/4208469-5341544, http://linkedlifedata.com/resource/pubmed/commentcorrection/4208469-5540168, http://linkedlifedata.com/resource/pubmed/commentcorrection/4208469-5647323, http://linkedlifedata.com/resource/pubmed/commentcorrection/4208469-5659331
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
AIM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Jun
pubmed:issn
0021-9738
pubmed:author
pubmed:issnType
Print
pubmed:volume
53
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
1568-77
pubmed:dateRevised
2009-11-18
pubmed:meshHeading
pubmed-meshheading:4208469-Ammonium Chloride, pubmed-meshheading:4208469-Animals, pubmed-meshheading:4208469-Anura, pubmed-meshheading:4208469-Biological Transport, pubmed-meshheading:4208469-Bufo marinus, pubmed-meshheading:4208469-Chromatography, Gel, pubmed-meshheading:4208469-Electrophysiology, pubmed-meshheading:4208469-Epithelial Cells, pubmed-meshheading:4208469-Epithelium, pubmed-meshheading:4208469-Humans, pubmed-meshheading:4208469-Kidney Failure, Chronic, pubmed-meshheading:4208469-Mucous Membrane, pubmed-meshheading:4208469-Natriuresis, pubmed-meshheading:4208469-Oxidation-Reduction, pubmed-meshheading:4208469-Potassium, pubmed-meshheading:4208469-Pyruvates, pubmed-meshheading:4208469-Serous Membrane, pubmed-meshheading:4208469-Sodium, pubmed-meshheading:4208469-Uremia, pubmed-meshheading:4208469-Urinary Bladder, pubmed-meshheading:4208469-Urine, pubmed-meshheading:4208469-Water-Electrolyte Balance
pubmed:year
1974
pubmed:articleTitle
The effects of the natriuretic factor from uremic urine on sodium transport, water and electrolyte content, and pyruvate oxidation by the isolated toad bladder.
pubmed:publicationType
Journal Article