rdf:type |
|
lifeskim:mentions |
|
pubmed:issue |
2
|
pubmed:dateCreated |
1974-5-16
|
pubmed:abstractText |
Immune sera to strains of Streptococcus mutans were found to inhibit agglutination of bacterial suspensions to which either high-molecular-weight dextran or sucrose was added. This inhibitory activity was shown to be mediated by antibody of the immunoglobulin G class. A semiquantitative assay was developed which demonstrated cross-inhibition of dextran/sucrose-induced agglutination among several strains of S. mutans. Antiserum to a partially purified glucosyltransferase was found to lack agglutination inhibition activity, consistent with the hypothesis that the dextran-binding antigen detected by the assay is immunologically distinct from the glucan-synthetic enzyme. A model for glucan synthesis and binding consistent with the reported data is described.
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pubmed:commentsCorrections |
|
pubmed:language |
eng
|
pubmed:journal |
|
pubmed:citationSubset |
IM
|
pubmed:chemical |
|
pubmed:status |
MEDLINE
|
pubmed:month |
Feb
|
pubmed:issn |
0019-9567
|
pubmed:author |
|
pubmed:issnType |
Print
|
pubmed:volume |
9
|
pubmed:owner |
NLM
|
pubmed:authorsComplete |
Y
|
pubmed:pagination |
273-8
|
pubmed:dateRevised |
2009-11-18
|
pubmed:meshHeading |
pubmed-meshheading:4205944-Absorption,
pubmed-meshheading:4205944-Agglutination,
pubmed-meshheading:4205944-Chromatography, Gel,
pubmed-meshheading:4205944-Chromatography, Ion Exchange,
pubmed-meshheading:4205944-Cross Reactions,
pubmed-meshheading:4205944-Dextrans,
pubmed-meshheading:4205944-Glucosyltransferases,
pubmed-meshheading:4205944-Immune Sera,
pubmed-meshheading:4205944-Immunodiffusion,
pubmed-meshheading:4205944-Methods,
pubmed-meshheading:4205944-Polysaccharides,
pubmed-meshheading:4205944-Streptococcus,
pubmed-meshheading:4205944-Sucrose
|
pubmed:year |
1974
|
pubmed:articleTitle |
Antibody-mediated inhibition of dextran-sucrose-induced agglutination of Streptococcus mutans.
|
pubmed:publicationType |
Journal Article,
Comparative Study
|