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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
4
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pubmed:dateCreated |
1970-9-9
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pubmed:abstractText |
This paper describes the characteristics of the indicator factor (I) which takes part in reactive hemolysis and its identification as the seventh component of complement. I was shown to be a beta globulin with a sediment coefficient of 5.7S and a molecular weight of about 140,000. Experiments on the depletion of I activity with anti-I antiserum or with activated R euglobulin showed that I was a late acting complement component necessary for the lysis of cells after the EAC142 stage. Complement component analysis of purified I fractions excluded all known components except C7. The physicochemical characteristics of I are compatible with published data on C7. The method of quantitation described represents a convenient method of testing for C7.
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/4193934-13792817,
http://linkedlifedata.com/resource/pubmed/commentcorrection/4193934-14416422,
http://linkedlifedata.com/resource/pubmed/commentcorrection/4193934-4163527,
http://linkedlifedata.com/resource/pubmed/commentcorrection/4193934-4165677,
http://linkedlifedata.com/resource/pubmed/commentcorrection/4193934-4172980,
http://linkedlifedata.com/resource/pubmed/commentcorrection/4193934-4193935,
http://linkedlifedata.com/resource/pubmed/commentcorrection/4193934-4956917,
http://linkedlifedata.com/resource/pubmed/commentcorrection/4193934-4959665,
http://linkedlifedata.com/resource/pubmed/commentcorrection/4193934-5891628,
http://linkedlifedata.com/resource/pubmed/commentcorrection/4193934-5922093,
http://linkedlifedata.com/resource/pubmed/commentcorrection/4193934-5960883
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
AIM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Apr
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pubmed:issn |
0022-1007
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:day |
1
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pubmed:volume |
131
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
629-41
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pubmed:dateRevised |
2010-6-22
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pubmed:meshHeading |
pubmed-meshheading:4193934-Animals,
pubmed-meshheading:4193934-Chromatography, DEAE-Cellulose,
pubmed-meshheading:4193934-Complement Inactivator Proteins,
pubmed-meshheading:4193934-Complement System Proteins,
pubmed-meshheading:4193934-Edetic Acid,
pubmed-meshheading:4193934-Erythrocytes,
pubmed-meshheading:4193934-Hemolysis,
pubmed-meshheading:4193934-Humans,
pubmed-meshheading:4193934-Immunodiffusion,
pubmed-meshheading:4193934-Immunoelectrophoresis,
pubmed-meshheading:4193934-Rabbits,
pubmed-meshheading:4193934-Ultracentrifugation,
pubmed-meshheading:4193934-gamma-Globulins
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pubmed:year |
1970
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pubmed:articleTitle |
Reactive lysis: the complement-mediated lysis of unsensitized cells. I. The characterization of the indicator factor and its identification as C7.
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pubmed:publicationType |
Journal Article
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