Linked Life Data

41886

Source:http://linkedlifedata.com/resource/pubmed/id/41886

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
2
pubmed:dateCreated
1980-2-15
pubmed:abstractText
Bovine pineal glands were subjected to extraction with dilute acetic acid, gel filtration on Sephadex G-25 and subsequent ultrafiltration through Diaflo membranes PM10, UM2 and UM05. Various fractions derived at each step were tested for the presence of substances which stimulate or inhibit prolactin secretion in vitro and in vivo. Both prolactin releasing (PPRF) and release-inhibiting (PPIF) activities were observed. PPRF activity was present in certain fractions derived from Sephadex G-25 and in the PM10 residue (MW congruent to less than 10,000). Whereas both the UM2 residue (MW greater than 1000) and UM05 filtrates (MW less than 500) was seen to inhibit pituitary prolactin release in vitro, the UM05 residue (MW greater than 500 and less than 1000) inhibited prolactin release in vivo, possibly by stimulating the secretion of the hypothalamic prolactin inhibiting factor. On the basis of its inactivation by trypsin it was concluded that PPIF may be a peptide or contain a peptide moiety indispensible for its biological activity. Experiments are in progress to characterize pineal prolactin-regulating activities and to elucidate further the physiological role of the pineal gland in the regulation of prolactin secretion.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:issn
0300-9564
pubmed:author
pubmed:issnType
Print
pubmed:volume
46
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
139-51
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed:year
1979
pubmed:articleTitle
Preliminary characterization of bovine pineal prolactin releasing (PPRF) and release-inhibiting factors (PPIF) activity.
pubmed:publicationType
Journal Article, Research Support, U.S. Gov't, P.H.S.