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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
4
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pubmed:dateCreated |
1969-5-1
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pubmed:abstractText |
A new heavy chain disease protein ((gamma)HCD-JM) has been characterized by antigenic and structural criteria. The protein belongs to the IgG3-subclass and is closely related to Fc-fragment of G3-immunoglobulins. The predominant N-terminal amino acid of this protein is glutamic acid in the uncyclized form, and that of another (gamma)HCD is glycine. Studies of the N-terminal peptides indicate that the N-terminal portion of the (gamma)3-heavy polypeptide chain is absent from the (gamma)HCD-JM. These findings rule out a process of normal heavy chain initiation and a large deletion of the Fd region as being responsible for these two heavy chain disease proteins. The (gamma)HCD-JM is a secretory product of cells from bone marrow as shown by studies of in vitro incorporation of amino acids-(14)C. Bone marrow and lymph node have a population of lymphoplasmacytic cells which by immunofluorescence contain (gamma)-heavy chain antigens in the absence of light chain antigens.
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/4180120-14082035,
http://linkedlifedata.com/resource/pubmed/commentcorrection/4180120-14186462,
http://linkedlifedata.com/resource/pubmed/commentcorrection/4180120-14209281,
http://linkedlifedata.com/resource/pubmed/commentcorrection/4180120-14209282,
http://linkedlifedata.com/resource/pubmed/commentcorrection/4180120-14247713,
http://linkedlifedata.com/resource/pubmed/commentcorrection/4180120-14268729,
http://linkedlifedata.com/resource/pubmed/commentcorrection/4180120-4159034,
http://linkedlifedata.com/resource/pubmed/commentcorrection/4180120-4166686,
http://linkedlifedata.com/resource/pubmed/commentcorrection/4180120-4166768,
http://linkedlifedata.com/resource/pubmed/commentcorrection/4180120-4167412,
http://linkedlifedata.com/resource/pubmed/commentcorrection/4180120-4167867,
http://linkedlifedata.com/resource/pubmed/commentcorrection/4180120-4168059,
http://linkedlifedata.com/resource/pubmed/commentcorrection/4180120-4172475,
http://linkedlifedata.com/resource/pubmed/commentcorrection/4180120-4173584,
http://linkedlifedata.com/resource/pubmed/commentcorrection/4180120-4174499,
http://linkedlifedata.com/resource/pubmed/commentcorrection/4180120-4178186,
http://linkedlifedata.com/resource/pubmed/commentcorrection/4180120-4382713,
http://linkedlifedata.com/resource/pubmed/commentcorrection/4180120-5243936
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
AIM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Apr
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pubmed:issn |
0021-9738
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
48
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
785-93
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pubmed:dateRevised |
2009-11-18
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pubmed:meshHeading |
pubmed-meshheading:4180120-Amino Acids,
pubmed-meshheading:4180120-Blood Proteins,
pubmed-meshheading:4180120-Bone Marrow,
pubmed-meshheading:4180120-Bone Marrow Cells,
pubmed-meshheading:4180120-Carbon Isotopes,
pubmed-meshheading:4180120-Fluorescent Antibody Technique,
pubmed-meshheading:4180120-Heavy Chain Disease,
pubmed-meshheading:4180120-Humans,
pubmed-meshheading:4180120-Immunoelectrophoresis,
pubmed-meshheading:4180120-Ultracentrifugation,
pubmed-meshheading:4180120-gamma-Globulins
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pubmed:year |
1969
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pubmed:articleTitle |
Biosynthetic and structural studies of a heavy chain disease protein.
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pubmed:publicationType |
Journal Article
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