| pubmed-article:417780 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:417780 | lifeskim:mentions | umls-concept:C0332307 | lld:lifeskim |
| pubmed-article:417780 | lifeskim:mentions | umls-concept:C0027573 | lld:lifeskim |
| pubmed-article:417780 | lifeskim:mentions | umls-concept:C0003320 | lld:lifeskim |
| pubmed-article:417780 | lifeskim:mentions | umls-concept:C0023810 | lld:lifeskim |
| pubmed-article:417780 | lifeskim:mentions | umls-concept:C0205214 | lld:lifeskim |
| pubmed-article:417780 | lifeskim:mentions | umls-concept:C0871161 | lld:lifeskim |
| pubmed-article:417780 | pubmed:issue | 2 | lld:pubmed |
| pubmed-article:417780 | pubmed:dateCreated | 1978-7-15 | lld:pubmed |
| pubmed-article:417780 | pubmed:abstractText | The ability of R-type lipopolysaccharide (LPS), isolated from Neisseria gonorrhoeae colony type 4, to protect against infection with N. gonorrhoea colony type 1 (T1 isolates) in the mouse and chicken embryo was investigated. C57 black mice were immunized intraperitoneally with 50 microgram of LPS, and challenged intracerebrally with 10-20 LD50's of N. gonorrhoeae colony type 1. Immunized mice were significantly protected (P less than 0.01 to less than 0.05) against challenge with different T1 isolates of N. gonorrhoeae when compared with non-immunized mice. Mice, injected with succinylated or alkali-treated LPS were not protected against gonococcal challenges. In a second animal model, leghorn hens were immunized intravenously with three injections of 500 microgram of LPS followed by a booster of 2.5 mg 2 weeks later. Embryonated eggs obtained from immunized hens were protected against challenge with 5 x 10(3) - 1 x 10(4) LD50's of three different T1 isolates. When hens were injected with the chemically modified LPS, the embryos were not resistant to gonococcal challenge. The results of this study demonstrate the ability of R-type gonococcal LPS to provide protection against different T1 isolates of N. gonorrhoeae. | lld:pubmed |
| pubmed-article:417780 | pubmed:language | eng | lld:pubmed |
| pubmed-article:417780 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:417780 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:417780 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:417780 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:417780 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:417780 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:417780 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:417780 | pubmed:month | Feb | lld:pubmed |
| pubmed-article:417780 | pubmed:issn | 0008-4166 | lld:pubmed |
| pubmed-article:417780 | pubmed:author | pubmed-author:WallaceRR | lld:pubmed |
| pubmed-article:417780 | pubmed:author | pubmed-author:RyanAA | lld:pubmed |
| pubmed-article:417780 | pubmed:author | pubmed-author:DienaB BBB | lld:pubmed |
| pubmed-article:417780 | pubmed:author | pubmed-author:AshtonF EFE | lld:pubmed |
| pubmed-article:417780 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:417780 | pubmed:volume | 24 | lld:pubmed |
| pubmed-article:417780 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:417780 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:417780 | pubmed:pagination | 117-23 | lld:pubmed |
| pubmed-article:417780 | pubmed:dateRevised | 2003-11-14 | lld:pubmed |
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| pubmed-article:417780 | pubmed:meshHeading | pubmed-meshheading:417780-I... | lld:pubmed |
| pubmed-article:417780 | pubmed:year | 1978 | lld:pubmed |
| pubmed-article:417780 | pubmed:articleTitle | The lipopolysaccharide (R type) as a common antigen of Neisseria gonorrhoeae. I. Immunizing properties. | lld:pubmed |
| pubmed-article:417780 | pubmed:publicationType | Journal Article | lld:pubmed |
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