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Predicate | Object |
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rdf:type | |
lifeskim:mentions | |
pubmed:issue |
2
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pubmed:dateCreated |
1978-7-15
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pubmed:abstractText |
The ability of R-type lipopolysaccharide (LPS), isolated from Neisseria gonorrhoeae colony type 4, to protect against infection with N. gonorrhoea colony type 1 (T1 isolates) in the mouse and chicken embryo was investigated. C57 black mice were immunized intraperitoneally with 50 microgram of LPS, and challenged intracerebrally with 10-20 LD50's of N. gonorrhoeae colony type 1. Immunized mice were significantly protected (P less than 0.01 to less than 0.05) against challenge with different T1 isolates of N. gonorrhoeae when compared with non-immunized mice. Mice, injected with succinylated or alkali-treated LPS were not protected against gonococcal challenges. In a second animal model, leghorn hens were immunized intravenously with three injections of 500 microgram of LPS followed by a booster of 2.5 mg 2 weeks later. Embryonated eggs obtained from immunized hens were protected against challenge with 5 x 10(3) - 1 x 10(4) LD50's of three different T1 isolates. When hens were injected with the chemically modified LPS, the embryos were not resistant to gonococcal challenge. The results of this study demonstrate the ability of R-type gonococcal LPS to provide protection against different T1 isolates of N. gonorrhoeae.
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pubmed:language |
eng
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pubmed:journal | |
pubmed:citationSubset |
IM
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pubmed:chemical | |
pubmed:status |
MEDLINE
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pubmed:month |
Feb
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pubmed:issn |
0008-4166
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pubmed:author | |
pubmed:issnType |
Print
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pubmed:volume |
24
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
117-23
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pubmed:dateRevised |
2003-11-14
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pubmed:meshHeading |
pubmed-meshheading:417780-Animals,
pubmed-meshheading:417780-Antibody Specificity,
pubmed-meshheading:417780-Antigens, Bacterial,
pubmed-meshheading:417780-Bacterial Vaccines,
pubmed-meshheading:417780-Chick Embryo,
pubmed-meshheading:417780-Female,
pubmed-meshheading:417780-Gonorrhea,
pubmed-meshheading:417780-Guinea Pigs,
pubmed-meshheading:417780-Immunization,
pubmed-meshheading:417780-Immunologic Techniques,
pubmed-meshheading:417780-Lipopolysaccharides,
pubmed-meshheading:417780-Mice,
pubmed-meshheading:417780-Mice, Inbred Strains,
pubmed-meshheading:417780-Neisseria gonorrhoeae,
pubmed-meshheading:417780-Polysaccharides, Bacterial
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pubmed:year |
1978
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pubmed:articleTitle |
The lipopolysaccharide (R type) as a common antigen of Neisseria gonorrhoeae. I. Immunizing properties.
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pubmed:publicationType |
Journal Article
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