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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
1
|
| pubmed:dateCreated |
1978-6-17
|
| pubmed:abstractText |
Mouse peritoneal macrophages were cultivated in vitro and treated with ethidium bromide (EB) or with cis-dichloro-diammine platinum (II) (cis-Pt). EB provokes strong cytological alterations and cell degeneration; cis-Pt was not toxic under our experimental contitions. EB-DNA complex penetrates into the macrophages, is liberated from DNA in vacuoles, then diffuses into the cell and is highly cytotoxic. Cis-Pt-DNA complex also penetrates into the cells, but cis-Pt cannot be released from DNA, cis-Pt-DNA complex accumulates inside cytoplasmic vacuoles but has no cytotoxic activity.
|
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:chemical | |
| pubmed:status |
MEDLINE
|
| pubmed:month |
Mar
|
| pubmed:issn |
0340-6075
|
| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:day |
2
|
| pubmed:volume |
27
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
79-87
|
| pubmed:dateRevised |
2003-11-14
|
| pubmed:meshHeading |
pubmed-meshheading:417459-Animals,
pubmed-meshheading:417459-Cells, Cultured,
pubmed-meshheading:417459-Cisplatin,
pubmed-meshheading:417459-DNA,
pubmed-meshheading:417459-Ethidium,
pubmed-meshheading:417459-Macrophages,
pubmed-meshheading:417459-Mice,
pubmed-meshheading:417459-Mice, Inbred C57BL,
pubmed-meshheading:417459-Microscopy, Electron,
pubmed-meshheading:417459-Mitosis,
pubmed-meshheading:417459-Peritoneum,
pubmed-meshheading:417459-Vacuoles
|
| pubmed:year |
1978
|
| pubmed:articleTitle |
Effects of antimitotic agents either free or bound to DNA on mouse peritoneal macrophages cultivated in vitro.
|
| pubmed:publicationType |
Journal Article
|