Linked Life Data

4169585

Source:http://linkedlifedata.com/resource/pubmed/id/4169585

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
2
pubmed:dateCreated
1968-3-3
pubmed:abstractText
This paper describes the trapping of antigen in lymphoid follicles of rat popliteal lymph nodes as revealed by electron microscopic radioautographs following injection of (125)I-labeled Salmonella adelaide flagella and other materials. The antigen was taken up vigorously, and to an approximately equal extent, by both primary and secondary follicles. The rate of uptake was faster in preimmunized than in virgin adult rats. The bulk of the antigen in follicles was extracellular, and persisted in this location for at least 3 wk. Label was most frequently found at or near the surface of fine cell processes. Many of these were branches of dendritic follicular reticular cells. Such processes interdigitated with equally fine processes of lymphocytes, creating an elaborate meshwork. In some cases, antigen was found between lymphocytes which appeared to be in close apposition. Occasionally, a few grains appeared over lymphocyte nuclei and study of serial sections suggested that this probably represented true entry of small amounts of antigen into lymphocytes. The characteristic "tingible body" macrophages (TBM) of germinal centers appeared to play only a secondary role in follicular antigen retention. They showed degrees of labeling over their phagocytic inclusions varying from negligible to moderately heavy. Moreover, follicles lacking or poor in TBM retained antigen just as effectively as those containing numerous TBM. The hypothesis is advanced that TBM may be derived from monocytes that migrate down from the circular sinus. Follicular localization of three other materials was also studied, though not in such detail. These were (125)I-HSA complexed to anti-HSA: (125)I-labeled autologous IgG; and (125)I-monomeric flagellin. All of these showed the basic features of intercellular, membrane-associated deposition noted with (125)I-flagella. The role of follicular antigen depots in immune induction is discussed. The tentative conclusion is reached that follicular antigen in a primary follicle encounters natural antibody on the surface of certain antigen-reactive lymphocytes. The resultant reaction causes blast cell transformation and eventually the genesis of a germinal center.
pubmed:commentsCorrections
http://linkedlifedata.com/resource/pubmed/commentcorrection/4169585-13879732, http://linkedlifedata.com/resource/pubmed/commentcorrection/4169585-14077999, http://linkedlifedata.com/resource/pubmed/commentcorrection/4169585-14165008, http://linkedlifedata.com/resource/pubmed/commentcorrection/4169585-14166255, http://linkedlifedata.com/resource/pubmed/commentcorrection/4169585-14238926, http://linkedlifedata.com/resource/pubmed/commentcorrection/4169585-14316952, http://linkedlifedata.com/resource/pubmed/commentcorrection/4169585-4161805, http://linkedlifedata.com/resource/pubmed/commentcorrection/4169585-4165744, http://linkedlifedata.com/resource/pubmed/commentcorrection/4169585-5337538, http://linkedlifedata.com/resource/pubmed/commentcorrection/4169585-5635379, http://linkedlifedata.com/resource/pubmed/commentcorrection/4169585-5840793, http://linkedlifedata.com/resource/pubmed/commentcorrection/4169585-5844810, http://linkedlifedata.com/resource/pubmed/commentcorrection/4169585-5855293, http://linkedlifedata.com/resource/pubmed/commentcorrection/4169585-5893802, http://linkedlifedata.com/resource/pubmed/commentcorrection/4169585-5926068, http://linkedlifedata.com/resource/pubmed/commentcorrection/4169585-5934923
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
AIM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Feb
pubmed:issn
0022-1007
pubmed:author
pubmed:issnType
Print
pubmed:day
1
pubmed:volume
127
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
277-90
pubmed:dateRevised
2010-6-22
pubmed:meshHeading
pubmed:year
1968
pubmed:articleTitle
Antigens in immunity. XV. Ultrastructural features of antigen capture in primary and secondary lymphoid follicles.
pubmed:publicationType
Journal Article