Linked Life Data

415986

Source:http://linkedlifedata.com/resource/pubmed/id/415986

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
5
pubmed:dateCreated
1978-5-24
pubmed:abstractText
An investigation has been made of the inhibitory activity of the so-called Hamburger pentapeptide, Asp-Ser-Asp-Pro-Arg, in both the human Prausnitz-Küstner and baboon passive cutaneous anaphylaxis systems. With a dose of 6 microgram peptide, administered intradermally 24 h prior to diluted allergic serum from a horse-dandruff-sensitive individual, partial inhibition of wealing was observed in three different normal recipients following the pricking in of specific allergen. In one of the recipients, inhibition of flaring was observed at test sites subsequently challenged with timothy grass pollen allergen. A similar dose of pentapeptide, again injected intradermally 24 h prior to passive sensitisation, was shown to inhibit extravasation in a normal baboon on subsequent challenge with horse dandruff (but not grass pollen) allergen by subcutaneous injection into the upper arm. In vivo tests performed in the forearms of grass-pollen-sensitive individuals failed to provide convincing evidence of displacement of mast-cell-bound IgE antibody by the pentapeptide.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:issn
0020-5915
pubmed:author
pubmed:issnType
Print
pubmed:volume
56
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
409-15
pubmed:dateRevised
2004-11-17
pubmed:meshHeading
pubmed:year
1978
pubmed:articleTitle
Investigation of the reputed inhibition of the Prausnitz-Küstner reaction by the pentapeptide Asp-Ser-Asp-Pro-Arg.
pubmed:publicationType
Journal Article