Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
3
pubmed:dateCreated
1966-1-17
pubmed:abstractText
The elasmobranch Mustelus canis has been shown to produce antibodies to Limulus hemocyanin. The serum of both normal and immunized M. canis contains immunoglobulins having sedimentation coefficients of approximately 7S and 17S. Antibody activity was found in the 17S immunoglobulin which may be dissociated to 7S components with concomitant loss of activity. Both 17S and 7S serum, immunoglobulins were antigenically identical. They consisted of light and heavy chains present in amounts comparable to those of higher vertebrates. Peptide maps indicated that the light chains had an entirely different primary structure than the heavy chains, but that the corresponding chains of 7S and 17S dogfish serum immunoglobulins were similar in primary structure. The heavy chains appeared to resemble the n chains of immunoglobulins of higher vertebrates in their starch gel electrophoretic behavior. It is suggested that the elasmobranch M. canis may have only one major class of immunoglobulins resembling that of macroglobulins (gammaM-immunoglobulins) seen in higher vertebrates. The results indicate that the multichain structure of antibodies is an ancient evolutionary development.
pubmed:commentsCorrections
http://linkedlifedata.com/resource/pubmed/commentcorrection/4158437-13163409, http://linkedlifedata.com/resource/pubmed/commentcorrection/4158437-13193528, http://linkedlifedata.com/resource/pubmed/commentcorrection/4158437-13409017, http://linkedlifedata.com/resource/pubmed/commentcorrection/4158437-13725659, http://linkedlifedata.com/resource/pubmed/commentcorrection/4158437-13767412, http://linkedlifedata.com/resource/pubmed/commentcorrection/4158437-13889152, http://linkedlifedata.com/resource/pubmed/commentcorrection/4158437-13939962, http://linkedlifedata.com/resource/pubmed/commentcorrection/4158437-13945475, http://linkedlifedata.com/resource/pubmed/commentcorrection/4158437-14046293, http://linkedlifedata.com/resource/pubmed/commentcorrection/4158437-14106306, http://linkedlifedata.com/resource/pubmed/commentcorrection/4158437-14113107, http://linkedlifedata.com/resource/pubmed/commentcorrection/4158437-14157031, http://linkedlifedata.com/resource/pubmed/commentcorrection/4158437-14163764, http://linkedlifedata.com/resource/pubmed/commentcorrection/4158437-14173001, http://linkedlifedata.com/resource/pubmed/commentcorrection/4158437-14270239, http://linkedlifedata.com/resource/pubmed/commentcorrection/4158437-14333020, http://linkedlifedata.com/resource/pubmed/commentcorrection/4158437-14803635, http://linkedlifedata.com/resource/pubmed/commentcorrection/4158437-14907713
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
AIM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Sep
pubmed:issn
0022-1007
pubmed:author
pubmed:issnType
Print
pubmed:day
1
pubmed:volume
122
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
601-18
pubmed:dateRevised
2010-11-18
pubmed:meshHeading
pubmed:year
1965
pubmed:articleTitle
Phylogenetic origins of antibody structure. I. Multichain structure of immunoglobulins in the smooth dogfish (Mustelus canis).
pubmed:publicationType
Journal Article, In Vitro